DPY30

This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Full Name
Dpy-30, Histone Methyltransferase Complex Regulatory Subunit
Function
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
Biological Process
Chromatin silencing at telomere Source: GO_Central
Endosomal transport Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Cellular Location
Trans-Golgi network; Nucleus. Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity).
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Anti-DPY30 antibodies

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Mouse Anti-DPY30 Recombinant Antibody (EG994) (CBMAB-EN1177-LY)

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Target: DPY30
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG994
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-DPY30 Recombinant Antibody (CBYCD-396) (CBMAB-D1639-YC)

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Target: DPY30
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-396
Application*: E, WB
Datasheet SDS

Mouse Anti-DPY30 Recombinant Antibody (EG994) (V2LY-0425-LY886)

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Target: DPY30
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG994
Application*: WB, E
Datasheet SDS

Mouse Anti-DPY30 Recombinant Antibody (CBYCD-396) (V2LY-0425-LY885)

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Target: DPY30
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYCD-396
Application*: IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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