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Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948)

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Published Data
Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948-1) in IHC
Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948-1) in IHC
Immunohistochemical staining of DSC1: red staining indicates DSC1 at the intercalated disc. ...View More
Ikawa-Yoshida, A., Matsumoto, T., Okano, S., Aoyagi, Y., Matsubara, Y., Furuyama, T., ... & Maehara, Y. (2016). BubR1 insufficiency impairs liver regeneration in aged mice after hepatectomy through intercalated disc abnormality. Scientific reports, 6(1), 32399.
Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948-2) in IHC
Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948-2) in IHC
BubR1 siRNA reduced DSC1 expression and disarrayed HaCaT cells. Control siRNA-transfected HaCaT cells (panels a1, a2, a3, and a4) and BubR1 siRNA-transfected HaCaT cells (panels b1, b2, b3, and b4) were stained using BubR1- (green) and DSC1-specific antibodies (red) and analyzed by confocal laser scanning microscopy. ...View More
Ikawa-Yoshida, A., Matsumoto, T., Okano, S., Aoyagi, Y., Matsubara, Y., Furuyama, T., ... & Maehara, Y. (2016). BubR1 insufficiency impairs liver regeneration in aged mice after hepatectomy through intercalated disc abnormality. Scientific reports, 6(1), 32399.
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
15H38
Application
FC, WB, IF, IHC
Immunogen
Mouse myeloma cell line derived recombinant mouse Desmocollin-1 (Arg135-Lys691).
Host Species
Rat
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB0.1 µg/ml
IF(ICC)8-25 µg/ml
IHC-P1-25 µg/ml
FC0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
desmocollin 1
Entrez Gene ID
13505
UniProt ID
P55849
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Biological Process
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Cellular Location
Cell membrane; Desmosome
Topology
Extracellular: 135-691
Helical: 692-714
Cytoplasmic: 715-894

Zhang, Z., Zhu, H., & Hu, J. (2021). CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell death & disease, 12(2), 1-12.

Faktor, J., Knopfova, L., Lapcik, P., Janacova, L., Paralova, V., Bouchalova, P., ... & Bouchal, P. (2019). Proteomics Identification and Validation of Desmocollin‐1 and Catechol‐O‐Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis. Proteomics, 19(21-22), 1900073.

Choi, H. Y., Ruel, I., Malina, A., Garrod, D. R., Oda, M. N., Pelletier, J., ... & Genest, J. (2018). Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. European Heart Journal, 39(14), 1194-1202.

Rhainds, D., Brodeur, M. R., Rautureau, Y., & Tardif, J. C. (2018). HDL biogenesis revisited: how desmocollin-1 could sabotage reverse cholesterol transport in the arterial wall. European Heart Journal.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Rat Anti-DSC1 Recombinant Antibody (15H38) (CAT#: CBMAB-D1710-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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