DSC1

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
Full Name
desmocollin 1
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Biological Process
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Cellular Location
Cell membrane; Desmosome
Topology
Extracellular: 135-691
Helical: 692-714
Cytoplasmic: 715-894
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Anti-DSC1 antibodies

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Rat Anti-DSC1 Recombinant Antibody (15H38) (CBMAB-D1710-YC)

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Target: DSC1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15H38
Application*: F, WB
Datasheet SDS

Mouse Anti-DSC1 Recombinant Antibody (A-4) (CBMAB-D1707-YC)

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Target: DSC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A-4
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DSC1 Recombinant Antibody (5F192) (CBMAB-D1706-YC)

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Target: DSC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F192
Application*: IH, WB
Datasheet SDS

Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948)

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Target: DSC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 15H38
Application*: F, WB, IF, IH
Datasheet SDS

Mouse Anti-DSC1 Recombinant Antibody (D1707) (V2LY-0425-LY947)

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Target: DSC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1707
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-DSC1 Recombinant Antibody (D1706) (V2LY-0425-LY946)

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Target: DSC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: D1706
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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