Mouse Anti-DSC1 Recombinant Antibody (5F192) (CBMAB-D1706-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Desmocollin 1 (DSC1). The antibody can be used for immunoassay techniques, such as IHC, WB.
See all DSC1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

5F192

Antibody Isotype

IgG1

Application

IHC, WB

Basic Information

Immunogen

Synthetic peptide corresponding to HQTLESVKGVGQGDTGRYATDWQC present within the intracellular part of human Desmocollin 1

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

desmocollin 1

Introduction

DSC1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target The protein. The desmosomal family members are arranged in two clusters on chromosome 18.At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.

Entrez Gene ID

1823

UniProt ID

Q08554

Alternative Names

Desmocollin 1; Desmosomal Glycoprotein 2/3; Cadherin Family Member 1; DG2/DG3; CDHF1; Desmocollin-1;

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

Biological Process

Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane; Desmosome

Topology

Extracellular: 135-691
Helical: 692-714
Cytoplasmic: 715-894

References

Zhang, Z., Zhu, H., & Hu, J. (2021). CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell death & disease, 12(2), 1-12.

Faktor, J., Knopfova, L., Lapcik, P., Janacova, L., Paralova, V., Bouchalova, P., ... & Bouchal, P. (2019). Proteomics Identification and Validation of Desmocollin‐1 and Catechol‐O‐Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis. Proteomics, 19(21-22), 1900073.

Choi, H. Y., Ruel, I., Malina, A., Garrod, D. R., Oda, M. N., Pelletier, J., ... & Genest, J. (2018). Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. European Heart Journal, 39(14), 1194-1202.

Rhainds, D., Brodeur, M. R., Rautureau, Y., & Tardif, J. C. (2018). HDL biogenesis revisited: how desmocollin-1 could sabotage reverse cholesterol transport in the arterial wall. European Heart Journal.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-DSC1 Recombinant Antibody (A-4)

Rat Anti-DSC1 Recombinant Antibody (15H38)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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