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Mouse Anti-DSC2 Recombinant Antibody (CF137) (CBMAB-FT343LY)

The product is antibody recognizes DSC2. The antibody CF137 immunoassay techniques such as: ELISA, WB.
See all DSC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CF137
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
desmocollin 2
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Desmocollin 2
Introduction
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Entrez Gene ID
Human1824
Mouse13506
UniProt ID
HumanQ02487
MouseP55292
Alternative Names
ARVD11, Cadherin family member 2, CDHF2, desmocollin 2, Desmocollin 3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesion Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Topology
Extracellular: 136-694
Helical: 695-715
Cytoplasmic: 716-901

Raya-Sandino, A., Luissint, A. C., Kusters, D. H., Narayanan, V., Flemming, S., Garcia-Hernandez, V., ... & Nusrat, A. (2021). Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Molecular biology of the cell, 32(8), 753-768.

Ahram, M., Abdullah, M. S., Mustafa, S. A., Alsafadi, D. B., & Battah, A. H. (2021). Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells. Cytoskeleton, 78(8), 391-399.

Flemming, S., Luissint, A. C., Kusters, D. H., Raya-Sandino, A., Fan, S., Zhou, D. W., ... & Nusrat, A. (2020). Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell, 31(6), 407-418.

Chen, D. Q., Shen, X. B., Zhang, S. H., Ye, G. Y., & Xu, S. H. (2019). Malignant Arrhythmia with Variants of Desmocollin-2 and Desmoplakin Genes A Case Report. International Heart Journal, 18-681.

Brodehl, A., Stanasiuk, C., Anselmetti, D., Gummert, J., & Milting, H. (2019). Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites. FEBS Open bio, 9(5), 996-1007.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Mazurek, S. R., Calway, T., Harmon, C., Farrell, P., & Kim, G. H. (2017). MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA, 6(2), 143-150.

Brodehl, A., Belke, D. D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., ... & Gerull, B. (2017). Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One, 12(3), e0174019.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

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For research use only. Not intended for any clinical use.

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