Rabbit Anti-DSC2 Recombinant Antibody (521) (V2LY-0425-LY949)

Name: Rabbit Anti-DSC2 Recombinant Antibody (521)
SKU: V2LY-0425-LY949
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

521

Application

ELISA

Immunogen

Recombinant Human DSC2 Protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Desmocollin 2

Entrez Gene ID

1824

UniProt ID

Q02487

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Biological Process

Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesion Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL

Cellular Location

Cell membrane; Desmosome

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Topology

Extracellular: 136-694
Helical: 695-715
Cytoplasmic: 716-901

Raya-Sandino, A., Luissint, A. C., Kusters, D. H., Narayanan, V., Flemming, S., Garcia-Hernandez, V., ... & Nusrat, A. (2021). Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Molecular biology of the cell, 32(8), 753-768.

Ahram, M., Abdullah, M. S., Mustafa, S. A., Alsafadi, D. B., & Battah, A. H. (2021). Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells. Cytoskeleton, 78(8), 391-399.

Flemming, S., Luissint, A. C., Kusters, D. H., Raya-Sandino, A., Fan, S., Zhou, D. W., ... & Nusrat, A. (2020). Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell, 31(6), 407-418.

Chen, D. Q., Shen, X. B., Zhang, S. H., Ye, G. Y., & Xu, S. H. (2019). Malignant Arrhythmia with Variants of Desmocollin-2 and Desmoplakin Genes A Case Report. International Heart Journal, 18-681.

Brodehl, A., Stanasiuk, C., Anselmetti, D., Gummert, J., & Milting, H. (2019). Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites. FEBS Open bio, 9(5), 996-1007.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Mazurek, S. R., Calway, T., Harmon, C., Farrell, P., & Kim, G. H. (2017). MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA, 6(2), 143-150.

Brodehl, A., Belke, D. D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., ... & Gerull, B. (2017). Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One, 12(3), e0174019.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Rabbit Anti-DSC2 Recombinant Antibody (521) (CAT#: CBMAB-D1713-YC)

Antibody Pairs

DSC2 Matched Antibody Pair (352) (CAT#: APMAB-352LY)

Related Products

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Mouse Anti-DSC2 Recombinant Antibody (CF137) (CAT#: CBMAB-FT343LY)

Mouse Anti-DSC2 Recombinant Antibody (118) (CAT#: CBMAB-AP1948LY)

Rabbit Anti-DSC2 Recombinant Antibody (521) (CAT#: CBMAB-D1713-YC)

Rabbit Anti-DSC2 Recombinant Antibody (023) (CAT#: CBMAB-D1715-YC)

Mouse Anti-DSC2 Recombinant Antibody (118) (CAT#: V2LY-0425-LY953)

Mouse Anti-DSC2 Recombinant Antibody (1F2) (CAT#: V2LY-0425-LY950)

Mouse Anti-DSC2 Recombinant Antibody (1F2) (CAT#: CBMAB-D1714-YC)

DSC2 Matched Antibody Pair (352) (CAT#: APMAB-352LY)

Mouse Anti-DSC2 Recombinant Antibody (CF137) (CAT#: V2LY-0425-LY952)

Isotype control

For research use only. Not intended for any clinical use.

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