DSC2

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Full Name
Desmocollin 2
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesion Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Topology
Extracellular: 136-694
Helical: 695-715
Cytoplasmic: 716-901
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Anti-DSC2 antibodies

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Mouse Anti-DSC2 Recombinant Antibody (118) (CBMAB-AP1948LY)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 118
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-DSC2 Recombinant Antibody (023) (CBMAB-D1715-YC)

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Target: DSC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 023
Application*: E
Datasheet SDS

Mouse Anti-DSC2 Recombinant Antibody (1F2) (CBMAB-D1714-YC)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F2
Application*: E, WB
Datasheet SDS

Rabbit Anti-DSC2 Recombinant Antibody (521) (CBMAB-D1713-YC)

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Target: DSC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 521
Application*: E
Datasheet SDS

Mouse Recombinant DSC2 protein, ECD, His Tag (V2LY-0526-LY8194)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-694
Tag: His Tag
Datasheet SDS

Human Recombinant DSC2 protein, His Tag-3 (V2LY-0526-LY3553)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 50-609
Tag: His Tag
In Vivo Assay
Datasheet SDS

Human Recombinant DSC2 protein, His Tag-2 (V2LY-0526-LY3552)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 50-609
Tag: His Tag
Datasheet SDS

Human Recombinant DSC2 protein, His Tag-1 (V2LY-0526-LY3551)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 136-684
Tag: His Tag
Datasheet SDS

Human Recombinant DSC2 protein, His Tag (V2LY-0526-LY3550)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-684
Tag: His Tag
Datasheet SDS

Rat Recombinant DSC2 protein, His Tag (V2LY-0526-LY9328)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-694
Tag: His Tag
Datasheet SDS

Rat Recombinant DSC2 protein, hFc Tag (V2LY-0526-LY9327)

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Target: DSC2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-694
Tag: hFc Tag
Datasheet SDS

Mouse Anti-DSC2 Recombinant Antibody (118) (V2LY-0425-LY953)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 118
Application*: E
Datasheet SDS

Mouse Anti-DSC2 Recombinant Antibody (CF137) (V2LY-0425-LY952)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF137
Application*: E
Datasheet SDS

Rabbit Anti-DSC2 Recombinant Antibody (023) (V2LY-0425-LY951)

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Target: DSC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 023
Application*: E
Datasheet SDS

Mouse Anti-DSC2 Recombinant Antibody (1F2) (V2LY-0425-LY950)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F2
Application*: E, WB
Datasheet SDS

Rabbit Anti-DSC2 Recombinant Antibody (521) (V2LY-0425-LY949)

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Target: DSC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 521
Application*: E
Datasheet SDS

DSC2 Matched Antibody Pair (352) (APMAB-352LY)

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Target: DSC2
Specificity: Human
Datasheet SDS

Mouse Anti-DSC2 Recombinant Antibody (CF137) (CBMAB-FT343LY)

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Target: DSC2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF137
Application*: ELISA, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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