Human Recombinant DSC2 protein, His Tag (V2LY-0526-LY3550)

Name: Human Recombinant DSC2 protein, His Tag
SKU: V2LY-0526-LY3550
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DSC2 protein, His Tag consist of Amino Acid: 1-684 and predicts a molecular mass of 75 kDa.

Molecule Mass

75 kDa

Sequence

Amino Acid: 1-684

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>75% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Desmocollin 2

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Biological Process

Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesion Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL

Cellular Location

Cell membrane; Desmosome

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Topology

Extracellular: 136-694
Helical: 695-715
Cytoplasmic: 716-901

Raya-Sandino, A., Luissint, A. C., Kusters, D. H., Narayanan, V., Flemming, S., Garcia-Hernandez, V., ... & Nusrat, A. (2021). Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Molecular biology of the cell, 32(8), 753-768.

Ahram, M., Abdullah, M. S., Mustafa, S. A., Alsafadi, D. B., & Battah, A. H. (2021). Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells. Cytoskeleton, 78(8), 391-399.

Flemming, S., Luissint, A. C., Kusters, D. H., Raya-Sandino, A., Fan, S., Zhou, D. W., ... & Nusrat, A. (2020). Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell, 31(6), 407-418.

Chen, D. Q., Shen, X. B., Zhang, S. H., Ye, G. Y., & Xu, S. H. (2019). Malignant Arrhythmia with Variants of Desmocollin-2 and Desmoplakin Genes A Case Report. International Heart Journal, 18-681.

Brodehl, A., Stanasiuk, C., Anselmetti, D., Gummert, J., & Milting, H. (2019). Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites. FEBS Open bio, 9(5), 996-1007.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Mazurek, S. R., Calway, T., Harmon, C., Farrell, P., & Kim, G. H. (2017). MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA, 6(2), 143-150.

Brodehl, A., Belke, D. D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., ... & Gerull, B. (2017). Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One, 12(3), e0174019.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Recombinant DSC2 protein, hFc Tag (CAT#: V2LY-0526-LY9327)

Rat Recombinant DSC2 protein, His Tag (CAT#: V2LY-0526-LY9328)

Human Recombinant DSC2 protein, His Tag-1 (CAT#: V2LY-0526-LY3551)

Human Recombinant DSC2 protein, His Tag-2 (CAT#: V2LY-0526-LY3552)

Human Recombinant DSC2 protein, His Tag-3 (CAT#: V2LY-0526-LY3553)

Mouse Recombinant DSC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY8194)

DSC2 Matched Antibody Pair (352) (CAT#: APMAB-352LY)

Antibody Pairs

DSC2 Matched Antibody Pair (352) (CAT#: APMAB-352LY)

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Rabbit Anti-DSC2 Recombinant Antibody (023) (CAT#: CBMAB-D1715-YC)

Human Recombinant DSC2 protein, His Tag-3 (CAT#: V2LY-0526-LY3553)

Rat Recombinant DSC2 protein, hFc Tag (CAT#: V2LY-0526-LY9327)

Mouse Anti-DSC2 Recombinant Antibody (CF137) (CAT#: V2LY-0425-LY952)

Mouse Anti-DSC2 Recombinant Antibody (1F2) (CAT#: V2LY-0425-LY950)

Mouse Recombinant DSC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY8194)

Mouse Anti-DSC2 Recombinant Antibody (118) (CAT#: V2LY-0425-LY953)

Isotype control

For research use only. Not intended for any clinical use.

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