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Mouse Anti-DSG1 Recombinant Antibody (62/Desmoglein) (CBMAB-D1750-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Desmoglein 1 (DSG1). The antibody can be used for immunoassay techniques, such as WB.
See all DSG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Chicken, Dog, Mouse, Rat
Clone
62/Desmoglein
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Human Desmoglein a.a.705-1029
Specificity
Human, Chicken, Dog, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Desmoglein 1
Introduction
DSG1 belongs to the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
Entrez Gene ID
Human1828
Mouse13510
Rat291755
Dog403401
UniProt ID
HumanQ02413
MouseQ61495
RatD4A4T7
DogQ9GKQ8
Alternative Names
Desmoglein 1; Pemphigus Foliaceus Antigen; Desmosomal Glycoprotein 1; Cadherin Family Member 4; CDHF4; DG1; Desmoglein-1;
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Protein stabilization Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1):
A dermatological disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE):
A syndrome characterized by severe dermatitis, multiple allergies and metabolic wasting. Clinical features include erythroderma, yellowish papules and plaques arranged at the periphery of the palms, along the fingers and over weight-bearing areas of the feet, skin erosions and scaling, and hypotrichosis. Additionally, patients manifest severe food allergies, elevated immunoglobulin E (IgE) levels and recurrent infections with marked metabolic wasting.
Topology
Extracellular: 50-548
Helical: 549-569
Cytoplasmic: 570-1049

Zimmer, S. E., Takeichi, T., Conway, D. E., Kubo, A., Suga, Y., Akiyama, M., & Kowalczyk, A. P. (2022). Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease. Journal of Investigative Dermatology, 142(2), 323-332.

Delavarian, Z., Layegh, P., Pakfetrat, A., Zarghi, N., Khorashadizadeh, M., & Ghazi, A. (2020). Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris: Correlation with disease severity. Journal of Clinical and Experimental Dentistry, 12(5), e440.

Arnette, C. R., Roth‐Carter, Q. R., Koetsier, J. L., Broussard, J. A., Burks, H. E., Cheng, K., ... & Green, K. J. (2020). Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling. Pigment cell & melanoma research, 33(2), 305-317.

Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., ... & Green, K. J. (2020). The role of desmoglein 1 in gap junction turnover revealed through the study of SAM syndrome. Journal of Investigative Dermatology, 140(3), 556-567.

Valenzuela-Iglesias, A., Burks, H. E., Arnette, C. R., Yalamanchili, A., Nekrasova, O., Godsel, L. M., & Green, K. J. (2019). Desmoglein 1 regulates invadopodia by suppressing EGFR/Erk signaling in an Erbin-dependent manner. Molecular Cancer Research, 17(5), 1195-1206.

Evangelista, F., Roth, A. J., Prisayanh, P., Temple, B. R., Li, N., Qian, Y., ... & Diaz, L. A. (2018). Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. Journal of autoimmunity, 89, 171-185.

Polivka, L., Hadj-Rabia, S., Bal, E., Leclerc-Mercier, S., Madrange, M., Hamel, Y., ... & Smahi, A. (2018). Epithelial barrier dysfunction in desmoglein-1 deficiency. Journal of Allergy and Clinical Immunology, 142(2), 702-706.

Lovgren, M. L., McAleer, M. A., Irvine, A. D., Wilson, N. J., Tavadia, S., Schwartz, M. E., ... & Zamiri, M. (2017). Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening. British Journal of Dermatology, 176(5), 1345-1350.

Yoshida, K., Ishii, K., Shimizu, A., Yokouchi, M., Amagai, M., Shiraishi, K., ... & Ishiko, A. (2017). Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. Journal of dermatological science, 85(3), 197-207.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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