Dog DSG1 ELISA Kit (V2LY-0626-LY231)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.17 ng/mL
Detection Range
0.2-70 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Dog
Assay Type
Sandwich
Reactivity
Dog
Assay Time
1.5 h
Molecule Mass
113.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Desmoglein 1
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Protein stabilization Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1):
A dermatological disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE):
A syndrome characterized by severe dermatitis, multiple allergies and metabolic wasting. Clinical features include erythroderma, yellowish papules and plaques arranged at the periphery of the palms, along the fingers and over weight-bearing areas of the feet, skin erosions and scaling, and hypotrichosis. Additionally, patients manifest severe food allergies, elevated immunoglobulin E (IgE) levels and recurrent infections with marked metabolic wasting.
Topology
Extracellular: 50-548
Helical: 549-569
Cytoplasmic: 570-1049

Zimmer, S. E., Takeichi, T., Conway, D. E., Kubo, A., Suga, Y., Akiyama, M., & Kowalczyk, A. P. (2022). Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease. Journal of Investigative Dermatology, 142(2), 323-332.

Delavarian, Z., Layegh, P., Pakfetrat, A., Zarghi, N., Khorashadizadeh, M., & Ghazi, A. (2020). Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris: Correlation with disease severity. Journal of Clinical and Experimental Dentistry, 12(5), e440.

Arnette, C. R., Roth‐Carter, Q. R., Koetsier, J. L., Broussard, J. A., Burks, H. E., Cheng, K., ... & Green, K. J. (2020). Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling. Pigment cell & melanoma research, 33(2), 305-317.

Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., ... & Green, K. J. (2020). The role of desmoglein 1 in gap junction turnover revealed through the study of SAM syndrome. Journal of Investigative Dermatology, 140(3), 556-567.

Valenzuela-Iglesias, A., Burks, H. E., Arnette, C. R., Yalamanchili, A., Nekrasova, O., Godsel, L. M., & Green, K. J. (2019). Desmoglein 1 regulates invadopodia by suppressing EGFR/Erk signaling in an Erbin-dependent manner. Molecular Cancer Research, 17(5), 1195-1206.

Evangelista, F., Roth, A. J., Prisayanh, P., Temple, B. R., Li, N., Qian, Y., ... & Diaz, L. A. (2018). Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. Journal of autoimmunity, 89, 171-185.

Polivka, L., Hadj-Rabia, S., Bal, E., Leclerc-Mercier, S., Madrange, M., Hamel, Y., ... & Smahi, A. (2018). Epithelial barrier dysfunction in desmoglein-1 deficiency. Journal of Allergy and Clinical Immunology, 142(2), 702-706.

Lovgren, M. L., McAleer, M. A., Irvine, A. D., Wilson, N. J., Tavadia, S., Schwartz, M. E., ... & Zamiri, M. (2017). Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening. British Journal of Dermatology, 176(5), 1345-1350.

Yoshida, K., Ishii, K., Shimizu, A., Yokouchi, M., Amagai, M., Shiraishi, K., ... & Ishiko, A. (2017). Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. Journal of dermatological science, 85(3), 197-207.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Dog DSG1 ELISA Kit (2) (CAT#: V2LY-0626-LY887)

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For research use only. Not intended for any clinical use.

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