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Mouse Anti-DYNC1I1 Recombinant Antibody (CBYCD-110) (CBMAB-D1990-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynein Cytoplasmic 1 Intermediate Chain 1 (DYNC1I1). The antibody can be used for immunoassay techniques, such as IHC-Fr, WB.
See all DYNC1I1 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CBYCD-110
Antibody Isotype
IgG2b
Application
IHC-Fr, WB

Basic Information

Immunogen
Native, from brain
Specificity
Cattle
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
dynein cytoplasmic 1 intermediate chain 1
Introduction
DYNC1I1 (Dynein Cytoplasmic 1 Intermediate Chain 1) is a protein coding gene. Diseases associated with DYNC1I1 include Paranoid Personality Disorder and Split-Hand/Foot Malformation 2. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. It has proved that the protein has microtubule binding and motor activity. And a paralog is DYNC1I2.
Entrez Gene ID
613724
UniProt ID
Q29RQ3
Alternative Names
Dynein Cytoplasmic 1 Intermediate Chain 1; Dynein, Cytoplasmic, Intermediate Polypeptide 1; Cytoplasmic Dynein Intermediate Chain 1; Dynein Intermediate Chain 1, Cytosolic; DH IC-1; DNCIC1; DNCI1; Cytoplasmic Dynein 1 Intermediate Chain 1;
Research Area
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Biological Process
Microtubule-based movement Source: GO_Central
Transport along microtubule Source: GO_Central
Vesicle transport along microtubule Source: UniProtKB
Cellular Location
Cytoplasm; Spindle pole; Kinetochore
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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