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Mouse Anti-EBV EBNA-1 Recombinant Antibody (CBMW-H1586) (V2LY-0425-LY1314)


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Summary

Host Animal
Mouse
Specificity
Epstein-Barr Virus
Clone
CBMW-H1586
Antibody Isotype
IgG2b
Application
ELISA

Basic Information

Immunogen
Epstein-Barr Virus nuclear antigen 1.
Host Species
Mouse
Specificity
Epstein-Barr Virus
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Epstein-Barr Virus Nuclear Antigen 1
Research Area
Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.
Biological Process
Positive regulation of transcription, DNA-templated Source: InterPro
Regulation of DNA replication Source: InterPro
Suppression by virus of host adaptive immune response Source: UniProtKB-KW
Suppression by virus of host antigen processing and presentation Source: UniProtKB-KW
Suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Viral latency Source: UniProtKB-KW
Cellular Location
Host nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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