EBV EBNA-1

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family, and is one of the most common viruses in humans.

Epstein-Barr Virus Nuclear Antigen 1

Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.

Positive regulation of transcription, DNA-templated Source: InterPro
Regulation of DNA replication Source: InterPro
Suppression by virus of host adaptive immune response Source: UniProtKB-KW
Suppression by virus of host antigen processing and presentation Source: UniProtKB-KW
Suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Viral latency Source: UniProtKB-KW

Host nucleus