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Rat Anti-ECE1 Recombinant Antibody (E0042) (V2LY-0425-LY1329)


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Summary

Host Animal
Rat
Specificity
Human
Clone
E0042
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant human ECE-1 (Gln90-Trp770).
Host Species
Rat
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Endothelin Converting Enzyme 1
Entrez Gene ID
1889
UniProt ID
P42892
Research Area
Converts big endothelin-1 to endothelin-1.
Biological Process
Bradykinin catabolic process Source: BHF-UCL
Calcitonin catabolic process Source: BHF-UCL
Ear development Source: BHF-UCL
Embryonic digit morphogenesis Source: BHF-UCL
Endothelin maturation Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Heart development Source: BHF-UCL
Hormone catabolic process Source: BHF-UCL
Peptide hormone processing Source: BHF-UCL
Pharyngeal system development Source: Ensembl
Positive regulation of receptor recycling Source: BHF-UCL
Protein processing Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: BHF-UCL
Substance P catabolic process Source: BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Hirschsprung disease, cardiac defects, and autonomic dysfunction (HCAD):
A disorder characterized by skip-lesions Hirschsprung disease, craniofacial abnormalities and other dysmorphic features, cardiac defects including ductus arteriosus, small subaortic ventricular septal defect, small atrial septal defect, and autonomic dysfunction.
Topology
Cytoplasmic: 1-68
Helical: 69-89
Extracellular: 90-770
More Infomation

Xie, H. (2022). Investigating the Potential Roles of Human (Endothelin convert enzyme-1) ECE-1 in Congenital Heart Diseases Using a Humanized Yeast System of Apoptosis (Doctoral dissertation, University of Leicester).

Hernández-Jiménez, C., Olmos-Zúñiga, J. R., Baltazares-Lipp, M., Jasso-Victoria, R., Polo-Jerez, A., Pérez-López, M. T., ... & Silva-Martínez, M. (2022). Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing. Disease Markers, 2022.

Arfian, N., Suzuki, Y., Hartopo, A. B., Anggorowati, N., Nugrahaningsih, D. A. A., & Emoto, N. (2020). Endothelin converting enzyme-1 (ECE-1) deletion in association with endothelin-1 downregulation ameliorates kidney fibrosis in mice. Life Sciences, 258, 118223.

McCormick, A., Kristianto, J., Wang, X., McIntosh, J., Cruz, M., Hibbard, J. U., & Blank, R. D. (2020). Placental endothelin-converting enzyme-1 is decreased in preeclampsia. Pregnancy hypertension, 20, 108-110.

Tapia, J. C., & Niechi, I. (2019). Endothelin-converting enzyme-1 in cancer aggressiveness. Cancer Letters, 452, 152-157.

Cho, T. J., Kim, H. J., & Cho, J. (2019). Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis. Animal Cells and Systems, 23(3), 170-175.

McCormick, A., Kristianto, J., Wang, X., Hibbard, J., McIntosh, J., Cruz, M., & Blank, R. (2019). 428: Preeclampsia is characterized by decreased expression of endothelin converting enzyme-1 in the placenta. American Journal of Obstetrics & Gynecology, 220(1), S290.

Heyman, S. N., Abassi, Z., Rosenberger, C., Yaseen, H., Skarjinski, G., Shina, A., ... & Khamaisi, M. (2018). Cyclosporine A induces endothelin‐converting enzyme‐1: Studies in vivo and in vitro. Acta Physiologica, 223(1), e13033.

Huangfu, W. (2018). GW29-e1565 Correlation of single-nucleotide polymorphisms of the 1C3435T and ECE-1 genes with the efficacy of irbesartan in primary hypertension. Journal of the American College of Cardiology, 72(16S), C157-C158.

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For research use only. Not intended for any clinical use.

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