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Rat Anti-ECE1 (AA 90-770) Recombinant Antibody (303913) (CBMAB-E0042-FY)

This product is rat antibody that recognizes ECE1. The antibody 303913 can be used for immunoassay techniques such as: FC, CyTOF.
See all ECE1 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
303913
Antibody Isotype
IgG1
Application
FC, CyTOF

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human ECE-1, Gln90-Trp770
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 90-770

Target

Full Name
Endothelin Converting Enzyme 1
Introduction
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction.
Entrez Gene ID
1889
UniProt ID
P42892
Alternative Names
ECE
Research Area
Converts big endothelin-1 to endothelin-1.
Biological Process
Bradykinin catabolic process Source: BHF-UCL
Calcitonin catabolic process Source: BHF-UCL
Ear development Source: BHF-UCL
Embryonic digit morphogenesis Source: BHF-UCL
Endothelin maturation Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Heart development Source: BHF-UCL
Hormone catabolic process Source: BHF-UCL
Peptide hormone processing Source: BHF-UCL
Pharyngeal system development Source: Ensembl
Positive regulation of receptor recycling Source: BHF-UCL
Protein processing Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: BHF-UCL
Substance P catabolic process Source: BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Hirschsprung disease, cardiac defects, and autonomic dysfunction (HCAD):
A disorder characterized by skip-lesions Hirschsprung disease, craniofacial abnormalities and other dysmorphic features, cardiac defects including ductus arteriosus, small subaortic ventricular septal defect, small atrial septal defect, and autonomic dysfunction.
Topology
Cytoplasmic: 1-68
Helical: 69-89
Extracellular: 90-770

Xie, H. (2022). Investigating the Potential Roles of Human (Endothelin convert enzyme-1) ECE-1 in Congenital Heart Diseases Using a Humanized Yeast System of Apoptosis (Doctoral dissertation, University of Leicester).

Hernández-Jiménez, C., Olmos-Zúñiga, J. R., Baltazares-Lipp, M., Jasso-Victoria, R., Polo-Jerez, A., Pérez-López, M. T., ... & Silva-Martínez, M. (2022). Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing. Disease Markers, 2022.

Arfian, N., Suzuki, Y., Hartopo, A. B., Anggorowati, N., Nugrahaningsih, D. A. A., & Emoto, N. (2020). Endothelin converting enzyme-1 (ECE-1) deletion in association with endothelin-1 downregulation ameliorates kidney fibrosis in mice. Life Sciences, 258, 118223.

McCormick, A., Kristianto, J., Wang, X., McIntosh, J., Cruz, M., Hibbard, J. U., & Blank, R. D. (2020). Placental endothelin-converting enzyme-1 is decreased in preeclampsia. Pregnancy hypertension, 20, 108-110.

Tapia, J. C., & Niechi, I. (2019). Endothelin-converting enzyme-1 in cancer aggressiveness. Cancer Letters, 452, 152-157.

Cho, T. J., Kim, H. J., & Cho, J. (2019). Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis. Animal Cells and Systems, 23(3), 170-175.

McCormick, A., Kristianto, J., Wang, X., Hibbard, J., McIntosh, J., Cruz, M., & Blank, R. (2019). 428: Preeclampsia is characterized by decreased expression of endothelin converting enzyme-1 in the placenta. American Journal of Obstetrics & Gynecology, 220(1), S290.

Heyman, S. N., Abassi, Z., Rosenberger, C., Yaseen, H., Skarjinski, G., Shina, A., ... & Khamaisi, M. (2018). Cyclosporine A induces endothelin‐converting enzyme‐1: Studies in vivo and in vitro. Acta Physiologica, 223(1), e13033.

Huangfu, W. (2018). GW29-e1565 Correlation of single-nucleotide polymorphisms of the 1C3435T and ECE-1 genes with the efficacy of irbesartan in primary hypertension. Journal of the American College of Cardiology, 72(16S), C157-C158.

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For research use only. Not intended for any clinical use.

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