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Mouse Anti-EDIL3 Recombinant Antibody (4C9) (CBMAB-A2452-LY)

The product is antibody recognizes EDIL3. The antibody 4C9 immunoassay techniques such as: WB, ELISA.
See all EDIL3 antibodies
Published Data
The cells were analyzed by western blotting for Del-1.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EDIL3 (NP_005702, 101 a.a. ~ 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EGF-like repeats and discoidin I-like domains 3
Introduction
The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq]
Entrez Gene ID
10085
UniProt ID
O43854
Alternative Names
DEL1; MGC26287
Research Area
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Biological Process
Cell adhesion Source: UniProtKB-KW
Positive regulation of cell-substrate adhesion Source: Ensembl
Cellular Location
Secreted

Niu, X., Han, Q., Li, X., Li, J., Liu, Y., Li, Y., ... & Zhang, K. (2022). EDIL3 influenced the αvβ3‐FAK/MEK/ERK axis of endothelial cells in psoriasis. Journal of Cellular and Molecular Medicine.

Niu, X., Han, Q., Li, X., Li, J., Liu, Y., Li, Y., ... & Zhang, K. (2022). EDIL3 influenced the αvβ3‐FAK/MEK/ERK axis of endothelial cells in psoriasis. Journal of Cellular and Molecular Medicine.

Sagkan, R. I., & Akin, D. F. B. (2021). Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 is a Novel Regulator of Epithelial-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma: In Silico Analysis. Erciyes Medical Journal, 43(2), 122-130.

AKIN, D. F., & ILIKCI, R. (2021). Mutations and expression profile of EDIL3 and correlation with HIF1A and tumor-associated carbonic anhydrases in pancreatic cancer. Clinical and Experimental Health Sciences, 11(3), 418-425.

Niu, X., Han, Q., Liu, Y., Li, J., Hou, R., Li, J., & Zhang, K. (2020). Psoriasis-associated angiogenesis is mediated by EDIL3. Microvascular Research, 132, 104056.

Gasca, J., Flores, M. L., Jiménez-Guerrero, R., Sáez, M. E., Barragán, I., Ruíz-Borrego, M., ... & Japón, M. A. (2020). EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells. Cell death discovery, 6(1), 1-14.

Kun, Z., Xin, G., Tao, W., Chenglong, Z., Dongsheng, W., Liang, T., ... & Jianru, X. (2019). Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model. Journal of bone oncology, 16, 100238.

Wei, X., Zhang, C., Xie, Z., Teng, X., Wang, Z., Zheng, H., ... & Li, J. (2019). EGF-like repeats and discoidin I-like domain 3 (EDIL3) deficiency improves post-myocardial infarction healing via neutrophil extracellular traps (NETs) mediated pro-inflammatory macrophage polarization.

Stapane, L., Le Roy, N., Hincke, M. T., & Gautron, J. (2019). The glycoproteins EDIL3 and MFGE8 regulate vesicle-mediated eggshell calcification in a new model for avian biomineralization. Journal of Biological Chemistry, 294(40), 14526-14545.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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