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Mouse Anti-EDIL3 Recombinant Antibody (4C9) (V2LY-0425-LY1401)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4C9
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 101-199 of human EDIL3.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EGF-like repeats and discoidin I-like domains 3
Entrez Gene ID
10085
UniProt ID
O43854
Research Area
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Biological Process
Cell adhesion Source: UniProtKB-KW
Positive regulation of cell-substrate adhesion Source: Ensembl
Cellular Location
Secreted
More Infomation

Niu, X., Han, Q., Li, X., Li, J., Liu, Y., Li, Y., ... & Zhang, K. (2022). EDIL3 influenced the αvβ3‐FAK/MEK/ERK axis of endothelial cells in psoriasis. Journal of Cellular and Molecular Medicine.

Niu, X., Han, Q., Li, X., Li, J., Liu, Y., Li, Y., ... & Zhang, K. (2022). EDIL3 influenced the αvβ3‐FAK/MEK/ERK axis of endothelial cells in psoriasis. Journal of Cellular and Molecular Medicine.

Sagkan, R. I., & Akin, D. F. B. (2021). Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 is a Novel Regulator of Epithelial-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma: In Silico Analysis. Erciyes Medical Journal, 43(2), 122-130.

AKIN, D. F., & ILIKCI, R. (2021). Mutations and expression profile of EDIL3 and correlation with HIF1A and tumor-associated carbonic anhydrases in pancreatic cancer. Clinical and Experimental Health Sciences, 11(3), 418-425.

Niu, X., Han, Q., Liu, Y., Li, J., Hou, R., Li, J., & Zhang, K. (2020). Psoriasis-associated angiogenesis is mediated by EDIL3. Microvascular Research, 132, 104056.

Gasca, J., Flores, M. L., Jiménez-Guerrero, R., Sáez, M. E., Barragán, I., Ruíz-Borrego, M., ... & Japón, M. A. (2020). EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells. Cell death discovery, 6(1), 1-14.

Kun, Z., Xin, G., Tao, W., Chenglong, Z., Dongsheng, W., Liang, T., ... & Jianru, X. (2019). Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model. Journal of bone oncology, 16, 100238.

Wei, X., Zhang, C., Xie, Z., Teng, X., Wang, Z., Zheng, H., ... & Li, J. (2019). EGF-like repeats and discoidin I-like domain 3 (EDIL3) deficiency improves post-myocardial infarction healing via neutrophil extracellular traps (NETs) mediated pro-inflammatory macrophage polarization.

Stapane, L., Le Roy, N., Hincke, M. T., & Gautron, J. (2019). The glycoproteins EDIL3 and MFGE8 regulate vesicle-mediated eggshell calcification in a new model for avian biomineralization. Journal of Biological Chemistry, 294(40), 14526-14545.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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