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Mouse Anti-EEF1D Recombinant Antibody (4B12) (V2LY-0425-LY1452)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IF

Basic Information

Immunogen
EEF1D (aa1-91) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Elongation Factor 1 Delta
Entrez Gene ID
1936
UniProt ID
P29692
Research Area
Isoform 1:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.

Isoform 2:
Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
Biological Process
Cellular response to ionizing radiation Source: UniProtKB
mRNA transcription Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of cell death Source: UniProtKB
Translational elongation Source: GO_Central
Cellular Location
Isoform 2: Nucleus
More Infomation

Xu, Q., Liu, Y., Wang, S., Wang, J., Liu, L., Xu, Y., & Qin, Y. (2022). Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatin. BMC cancer, 22(1), 1-15.

Xu, H., Yu, S., Peng, K., Gao, L., Chen, S., Shen, Z., ... & Kang, M. (2021). The role of EEF1D in disease pathogenesis: a narrative review. Annals of Translational Medicine, 9(20).

Hou, Y., Xie, Y., Yang, S., Han, B., Shi, L., Bai, X., ... & Sun, D. (2021). EEF1D facilitates milk lipid synthesis by regulation of PI3K‐Akt signaling in mammals. The FASEB Journal, 35(5), e21455.

Xie, C., Zhou, M., Lin, J., Wu, Z., Ding, S., Luo, J., ... & Song, Y. (2020). EEF1D promotes glioma proliferation, migration, and invasion through EMT and PI3K/Akt pathway. BioMed Research International, 2020.

BİTERGE SÜT, B., & İKİNCİ KELEŞ, A. (2020). Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine Therapy. Oncologie, 22(3).

Ugur Iseri, S. A., Yucesan, E., Tuncer, F. N., Calik, M., Kesim, Y., Altiokka Uzun, G., & Ozbek, U. (2019). Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability. Journal of Human Genetics, 64(5), 421-426.

Cheng, D. D., Li, S. J., Zhu, B., Zhou, S. M., & Yang, Q. C. (2018). EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling. Journal of Experimental & Clinical Cancer Research, 37(1), 1-10.

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For research use only. Not intended for any clinical use.

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