Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0476) (CBMAB-E0823-FY)

Name: Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0476)
SKU: CBMAB-E0823-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0476

Application

WB, IF

Immunogen

Synthetic Peptide

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

EF-Hand Domain Family Member D1

Introduction

This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	80303
Mouse	98363
Rat	501181

UniProt ID

Human	Q9BUP0
Mouse	Q9D4J1
Rat	D4A9T5

Alternative Names

EF-Hand Domain Family Member D1; Swiprosin-2; EF-Hand Domain-Containing Protein 1; SWS2; EF-Hand Domain-Containing Protein D1; EF Hand Domain Containing 1; MSTP133; MST133; PP3051

Research Area

Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899).

May play a role in neuronal differentiation (By similarity).

Biological Process

Neuron projection development Source: Ensembl
Regulation of cellular hyperosmotic salinity response Source: UniProtKB

Cellular Location

Mitochondrion inner membrane

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E. C., Kraiss, J. N., ... & Chaudhuri, D. (2022). EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia. Journal of Molecular and Cellular Cardiology, 167, 1-14.

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E., Kraiss, J. N., ... & Chaudhuri, D. (2021). EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia. bioRxiv.

Eberhardt, D. R., Yin, X., Balynas, A., Lee, S., Walsh, M., Funai, K., & Chaudhuri, D. (2021, September). Abstract P339: Examining Cardiac Phenotypes Of EF Hand Containing Domain 1 Protein (EFHD1) Knockout Mice. In Circulation Research (Vol. 129, No. Suppl_1, pp. AP339-AP339). Hagerstown, MD: Lippincott Williams & Wilkins.

Mun, S. A., Park, J., Park, K. R., Lee, Y., Kang, J. Y., Park, T., ... & Eom, S. H. (2021). Structural and biochemical characterization of EFhd1/Swiprosin-2, an actin-binding protein in mitochondria. Frontiers in cell and developmental biology, 8, 628222.

Ulisse, V., Dey, S., Rothbard, D. E., Zeevi, E., Gokhman, I., Dadosh, T., ... & Yaron, A. (2020). Regulation of axonal morphogenesis by the mitochondrial protein Efhd1. Life science alliance, 3(7).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0476) (CAT#: V2LY-0425-LY1492)

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Isotype control

For research use only. Not intended for any clinical use.

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