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Rat Anti-EFNA2 Recombinant Antibody (CBFYE-0486) (CBMAB-E0835-FY)

This product is rat antibody that recognizes EFNA2. The antibody CBFYE-0486 can be used for immunoassay techniques such as: WB.
See all EFNA2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYE-0486
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse Ephrin-A2
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ephrin A2
Introduction
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
Entrez Gene ID
13637
UniProt ID
P52801
Alternative Names
Elf1; Epl6; CEK7L; Eplg6; Lerk6
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
Biological Process
Axon guidance Source: GO_Central
Bone remodeling Source: UniProtKB
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: UniProtKB
Olfactory bulb development Source: Ensembl
Osteoclast differentiation Source: UniProtKB
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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