Mouse Anti-EFNB3 Recombinant Antibody (CBFYE-0508) (CBMAB-E0864-FY)

Name: Mouse Anti-EFNB3 Recombinant Antibody (CBFYE-0508)
SKU: CBMAB-E0864-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0508

Application

Immunogen

Recombinant protein corresponding to human Ephrin-B3

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ephrin B3

Introduction

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Entrez Gene ID

1949

UniProt ID

Q15768

Alternative Names

Ephrin B3; EPH-Related Receptor Transmembrane Ligand ELK-L3; Ephrin-B3; EPLG8; LERK8; Eph-Related Receptor Tyrosine Kinase Ligand 8; EPH-Related Receptor Tyrosine Kinase Ligand 8; LERK-8; EFL6

Research Area

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

(Microbial infection) Acts as a receptor for nipah virus and hendra virus.

Biological Process

Adult walking behavior Source: Ensembl
Axon choice point recognition Source: Ensembl
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: MGI
Negative regulation of axonogenesis Source: ARUK-UCL
Nervous system development Source: ProtInc
T cell costimulation Source: Ensembl
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 28-226
Helical: 227-247
Cytoplasmic: 248-340

Wu, T., Zhang, B. Q., Raelson, J., Yao, Y. M., Wu, H. D., Xu, Z. X., ... & Hu, S. J. (2018). Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism. Scientific reports, 8(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-EFNB3 Recombinant Antibody (CBFYE-0508) (CAT#: V2LY-0425-LY1527)

Related Products

Mouse Anti-EFNB3 Recombinant Antibody (CBFYE-0508) (CAT#: V2LY-0425-LY1527)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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