Mouse Anti-EGFL7 Recombinant Antibody (3G1) (V2LY-0425-LY1548)

Name: Mouse Anti-EGFL7 Recombinant Antibody (3G1)
SKU: V2LY-0425-LY1548
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G1

Application

ELISA

Immunogen

Full length recombinant EGFL7.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

EGF Like Domain Multiple 7

Entrez Gene ID

51162

UniProt ID

Q9UHF1

Research Area

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Biological Process

Anatomical structure development Source: GO_Central
Angiogenesis Source: UniProtKB-KW
Blood vessel development Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Negative regulation of Notch signaling pathway Source: MGI
Positive regulation of endothelial cell proliferation Source: MGI
Vasculogenesis Source: UniProtKB

Cellular Location

Extracellular space

Ortega, M. A., Asunsolo, A., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., ... & García‑Honduvilla, N. (2021). An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Molecular medicine reports, 24(2), 1-9.

Heissig, B., Salama, Y., Takahashi, S., Okumura, K., & Hattori, K. (2021). The multifaceted roles of EGFL7 in cancer and drug resistance. Cancers, 13(5), 1014.

Massimiani, M., Salvi, S., Tiralongo, G. M., Moresi, S., Stuhlmann, H., Valensise, H., ... & Campagnolo, L. (2021). Circulating EGFL7 distinguishes between IUGR and PE: An observational case–control study. Scientific Reports, 11(1), 1-8.

Bill, M., Pathmanathan, A., Karunasiri, M., Shen, C., Burke, M. H., Ranganathan, P., ... & Dorrance, A. M. (2020). EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid LeukemiaTargeting EGFL7 in AML. Clinical Cancer Research, 26(3), 669-678.

Liu, Q., He, H., Yuan, Y., Zeng, H., Wang, Z., & Luo, W. (2020). Novel expression of EGFL7 in osteosarcoma and sensitivity to cisplatin. Frontiers in Oncology, 10, 74.

Usuba, R., Pauty, J., Soncin, F., & Matsunaga, Y. T. (2019). EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model. Biomaterials, 197, 305-316.

Richter, A., Alexdottir, M. S., Magnus, S. H., Richter, T. R., Morikawa, M., Zwijsen, A., & Valdimarsdottir, G. (2019). EGFL7 mediates BMP9-induced sprouting angiogenesis of endothelial cells derived from human embryonic stem cells. Stem cell reports, 12(6), 1250-1259.

Larochelle, C., Uphaus, T., Broux, B., Gowing, E., Paterka, M., Michel, L., ... & Zipp, F. (2018). EGFL7 reduces CNS inflammation in mouse. Nature communications, 9(1), 1-12.

Dudvarski Stanković, N., Bicker, F., Keller, S., Jones, D. T., Harter, P. N., Kienzle, A., ... & Schmidt, M. H. (2018). EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors. EMBO molecular medicine, 10(9), e8420.

Hong, G., Kuek, V., Shi, J., Zhou, L., Han, X., He, W., ... & Xu, J. (2018). EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. Journal of cellular physiology, 233(11), 8526-8537.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

EGFL7 Matched Antibody Pair (368) (CAT#: APMAB-368LY)

EGFL7 Matched Antibody Pair (369) (CAT#: APMAB-369LY)

EGFL7 Matched Antibody Pair (370) (CAT#: APMAB-370LY)

Related Products

Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0043) (CAT#: CBMAB-E0097-FY)

EGFL7 Matched Antibody Pair (369) (CAT#: APMAB-369LY)

Human Anti-EGFL7 Recombinant Antibody (CBFYE-0540) (CAT#: V2LY-0425-LY1542)

Mouse Anti-EGFL7 Recombinant Antibody (2H6) (CAT#: V2LY-0425-LY1547)

Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0542) (CAT#: V2LY-0425-LY1544)

EGFL7 Matched Antibody Pair (370) (CAT#: APMAB-370LY)

Rat Anti-EGFL7 Recombinant Antibody (CBYY-1024) (CAT#: CBMAB-1028-YY)

EGFL7 Matched Antibody Pair (368) (CAT#: APMAB-368LY)

Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0543) (CAT#: V2LY-0425-LY1545)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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