Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0043) (CBMAB-E0097-FY)

Name: Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0043)
SKU: CBMAB-E0097-FY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0043) (CBMAB-E0097-FY-1) in WB

Agomir-338-3p was transiently transfected in U87 and U118 cells that were stably overexpressed EGFL7 with or without 3'-UTR. Effects of co-transfection of agomir-338-3p and EGFL7 with or without 3'-UTR on EGFL7 protein level was measured. ...View More

Yu, H., Zheng, J., Liu, X., Xue, Y., Shen, S., Zhao, L., ... & Liu, Y. (2017). Transcription factor NFAT5 promotes glioblastoma cell-driven angiogenesis via SBF2-AS1/miR-338-3p-mediated EGFL7 expression change. Frontiers in Molecular Neuroscience, 10, 301.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0043

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 184-273 mapping at the C-terminus of human EGFL7.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

EGF Like Domain Multiple 7

Introduction

This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

51162

UniProt ID

Q9UHF1

Alternative Names

EGF Like Domain Multiple 7; Multiple Epidermal Growth Factor-Like Domains Protein 7; Multiple EGF-Like Domains Protein 7; Vascular Endothelial Statin; NOTCH4-Like Protein; EGF-Like Protein 7; VE-STATIN

Research Area

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Biological Process

Anatomical structure development Source: GO_Central
Angiogenesis Source: UniProtKB-KW
Blood vessel development Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Negative regulation of Notch signaling pathway Source: MGI
Positive regulation of endothelial cell proliferation Source: MGI
Vasculogenesis Source: UniProtKB

Cellular Location

Extracellular space

Ortega, M. A., Asunsolo, A., Fraile‑Martínez, O., Sainz, F., Saez, M. A., Bravo, C., ... & García‑Honduvilla, N. (2021). An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level. Molecular medicine reports, 24(2), 1-9.

Heissig, B., Salama, Y., Takahashi, S., Okumura, K., & Hattori, K. (2021). The multifaceted roles of EGFL7 in cancer and drug resistance. Cancers, 13(5), 1014.

Massimiani, M., Salvi, S., Tiralongo, G. M., Moresi, S., Stuhlmann, H., Valensise, H., ... & Campagnolo, L. (2021). Circulating EGFL7 distinguishes between IUGR and PE: An observational case–control study. Scientific Reports, 11(1), 1-8.

Bill, M., Pathmanathan, A., Karunasiri, M., Shen, C., Burke, M. H., Ranganathan, P., ... & Dorrance, A. M. (2020). EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid LeukemiaTargeting EGFL7 in AML. Clinical Cancer Research, 26(3), 669-678.

Liu, Q., He, H., Yuan, Y., Zeng, H., Wang, Z., & Luo, W. (2020). Novel expression of EGFL7 in osteosarcoma and sensitivity to cisplatin. Frontiers in Oncology, 10, 74.

Usuba, R., Pauty, J., Soncin, F., & Matsunaga, Y. T. (2019). EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model. Biomaterials, 197, 305-316.

Richter, A., Alexdottir, M. S., Magnus, S. H., Richter, T. R., Morikawa, M., Zwijsen, A., & Valdimarsdottir, G. (2019). EGFL7 mediates BMP9-induced sprouting angiogenesis of endothelial cells derived from human embryonic stem cells. Stem cell reports, 12(6), 1250-1259.

Larochelle, C., Uphaus, T., Broux, B., Gowing, E., Paterka, M., Michel, L., ... & Zipp, F. (2018). EGFL7 reduces CNS inflammation in mouse. Nature communications, 9(1), 1-12.

Dudvarski Stanković, N., Bicker, F., Keller, S., Jones, D. T., Harter, P. N., Kienzle, A., ... & Schmidt, M. H. (2018). EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors. EMBO molecular medicine, 10(9), e8420.

Hong, G., Kuek, V., Shi, J., Zhou, L., Han, X., He, W., ... & Xu, J. (2018). EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. Journal of cellular physiology, 233(11), 8526-8537.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

EGFL7 Matched Antibody Pair (368) (CAT#: APMAB-368LY)

EGFL7 Matched Antibody Pair (369) (CAT#: APMAB-369LY)

EGFL7 Matched Antibody Pair (370) (CAT#: APMAB-370LY)

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Rat Anti-EGFL7 Recombinant Antibody (CBYY-1024) (CAT#: CBMAB-1028-YY)

EGFL7 Matched Antibody Pair (369) (CAT#: APMAB-369LY)

EGFL7 Matched Antibody Pair (368) (CAT#: APMAB-368LY)

Mouse Anti-EGFL7 Recombinant Antibody (3G1) (CAT#: V2LY-0425-LY1548)

Mouse Anti-EGFL7 Recombinant Antibody (2H6) (CAT#: V2LY-0425-LY1547)

Mouse Anti-EGFL7 Recombinant Antibody (CBFYE-0543) (CAT#: V2LY-0425-LY1545)

EGFL7 Matched Antibody Pair (370) (CAT#: APMAB-370LY)

Isotype control

For research use only. Not intended for any clinical use.

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