EGFL7
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Full Name
EGF Like Domain Multiple 7
Research Area
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.
Biological Process
Anatomical structure development Source: GO_Central
Angiogenesis Source: UniProtKB-KW
Blood vessel development Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Negative regulation of Notch signaling pathway Source: MGI
Positive regulation of endothelial cell proliferation Source: MGI
Vasculogenesis Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Blood vessel development Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Negative regulation of Notch signaling pathway Source: MGI
Positive regulation of endothelial cell proliferation Source: MGI
Vasculogenesis Source: UniProtKB
Cellular Location
Extracellular space
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Anti-EGFL7 antibodies
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Target: EGFL7
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-1024
Application*: WB
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0043
Application*: WB, IP, IF, E
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G1
Application*: E
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2H6
Application*: WB, E
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0543
Application*: WB
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0542
Application*: IH
Target: EGFL7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0540
Application*: WB
Target: EGFL7
Specificity: Human
Target: EGFL7
Specificity: Human
Target: EGFL7
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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