Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467) (V2LY-0625-LY1934)

Name: Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467)
SKU: V2LY-0625-LY1934
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467) (V2LY-0625-LY1934) in WB

Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467) (V2LY-0625-LY1934) in IF

Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467) (V2LY-0625-LY1934) in FC

Mouse Anti-EIF2B3 Recombinant Antibody (CBT3467) (V2LY-0625-LY1934) in IHC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT3467

Application

WB, IHC, ICC, FC

Immunogen

Purified recombinant fragment of human EI2BG expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:50-1:200
FC	1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Eukaryotic Translation Initiation Factor 2B Subunit Gamma

Entrez Gene ID

8891

UniProt ID

Q9NR50

Research Area

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Biological Process

Cytoplasmic translational initiation Source: GO_Central
Hippocampus development Source: Ensembl
Oligodendrocyte development Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB

Cellular Location

Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2B complex; Guanyl-nucleotide exchange factor complex

Involvement in disease

Leukodystrophy with vanishing white matter (VWM):
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.

Xu, L., Zhong, M., Yang, Y., Wang, M., An, N., Xu, X., ... & Zheng, X. (2022). Adult-onset vanishing white matter in a patient with EIF2B3 variants misdiagnosed as multiple sclerosis. Neurological Sciences, 43(4), 2659-2667.

Wongkittichote, P., Mar, S. S., McKinstry, R. C., & Nguyen, H. (2022). Case Report: A Novel EIF2B3 Pathogenic Variant in Central Nervous System Hypomyelination/Vanishing White Matter. Frontiers in Genetics, 13.

Lee, Y. R., Kim, S. H., Ben-Mahmoud, A., Kim, O. H., Choi, T. I., Lee, K. H., ... & Kim, C. H. (2021). Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish. Human Molecular Genetics, 30(5), 331-342.

Khorrami, M., Khorram, E., Yaghini, O., Rezaei, M., Hejazifar, A., Iravani, O., ... & Kheirollahi, M. (2021). Identification of a missense variant in the EIF2B3 gene causing vanishing White matter disease with antenatal-onset but mild symptoms and Long-term survival. Journal of Molecular Neuroscience, 71(11), 2405-2414.

Hyun, S. E., Choi, B. S., Jang, J. H., Jeon, I., Jang, D. H., & Ryu, J. S. (2019). Correlation between vanishing white matter disease and novel heterozygous EIF2B3 variants using next-generation sequencing: a case report. Annals of Rehabilitation Medicine, 43(2), 234-238.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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