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Mouse Anti-EIF2B3 Recombinant Antibody (CBFYE-0653) (CBMAB-E1066-FY)

This product is mouse antibody that recognizes EIF2B3. The antibody CBFYE-0653 can be used for immunoassay techniques such as: WB, IHC.
See all EIF2B3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0653
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human EIF2B3 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 2B Subunit Gamma
Introduction
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
8891
UniProt ID
Q9NR50
Alternative Names
Eukaryotic Translation Initiation Factor 2B Subunit Gamma; Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa; EIF-2B GDP-GTP Exchange Factor Subunit Gamma; Eukaryotic Translation Initiation Factor 2B, Subunit 3 (Gamma, 58kD); Translation Initiation Factor EIF-2B Subunit Gamma; EIF2Bgamma; EIF-2B
Research Area
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Biological Process
Cytoplasmic translational initiation Source: GO_Central
Hippocampus development Source: Ensembl
Oligodendrocyte development Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB
Cellular Location
Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2B complex; Guanyl-nucleotide exchange factor complex
Involvement in disease
Leukodystrophy with vanishing white matter (VWM):
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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