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Mouse Anti-ELK3 Recombinant Antibody (CBFYE-0783) (CBMAB-E1228-FY)

This product is mouse antibody that recognizes ELK3. The antibody CBFYE-0783 can be used for immunoassay techniques such as: FC, IF, WB.
See all ELK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog
Clone
CBFYE-0783
Antibody Isotype
IgG2a
Application
FC, IF, WB

Basic Information

Immunogen
ELK3 antibody was raised in mouse using a full length recombinant protein of human ELK3 produced in HEK293T cells, as the immunogen
Specificity
Human, Dog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELK3, ETS Transcription Factor
Introduction
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human2004
Dog482613
UniProt ID
HumanP41970
DogE2QVW3
Alternative Names
ELK3, ETS Transcription Factor; SRF Accessory Protein 2; ELK3, ETS-Domain Protein (SRF Accessory Protein 2); Serum Response Factor Accessory Protein 2; ETS-Related Protein ERP; ETS-Related Protein NET
Research Area
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Biological Process
Angiogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Wound healing Source: Ensembl
Cellular Location
Nucleus

Ma, S., Wang, H., Li, W., Yan, Z., Luo, X., & Lu, P. (2022). RREB1 promotes the development of parafollicular carcinogenesis through the Ras-Raf-1-ELK3 signaling pathway. Nucleosides, Nucleotides & Nucleic Acids, 1-10.

Liu, N., He, J., Fan, D., Gu, Y., Wang, J., Li, H., ... & Fan, Z. (2022). Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Nature communications, 13(1), 1-14.

Zhang, J., Song, H., Chen, C., Chen, L., Dai, Y., Sun, P. H., ... & Wang, X. (2021). Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3. Pharmacological Research, 172, 105814.

Mao, Y., Li, W., Hua, B., Gu, X., Pan, W., Chen, Q., ... & Lu, C. (2020). Silencing of ELK3 induces SM phase arrest and apoptosis and upregulates SERPINE1 expression reducing migration in prostate cancer cells. BioMed Research International, 2020.

Meng, L., Xing, Z., Guo, Z., & Liu, Z. (2020). LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to promote bladder cancer progression. Cell death & disease, 11(12), 1-15.

Kim, H. K., Park, J. D., Choi, S. H., Shin, D. J., Hwang, S., Jung, H. Y., & Park, K. S. (2020). Functional link between miR-200a and ELK3 regulates the metastatic nature of breast cancer. Cancers, 12(5), 1225.

Wang, S., Li, J., & Yang, X. (2019). Long non-coding RNA LINC00525 promotes the stemness and chemoresistance of colorectal cancer by targeting miR-507/ELK3 axis. International journal of stem cells, 12(2), 347-359.

Kim, K. S., Park, J. I., Oh, N., Cho, H. J., Park, J. H., & Park, K. S. (2019). ELK3 expressed in lymphatic endothelial cells promotes breast cancer progression and metastasis through exosomal miRNAs. Scientific reports, 9(1), 1-10.

Cho, H. J., Oh, N., Park, J. H., Kim, K. S., Kim, H. K., Lee, E., ... & Park, K. S. (2019). ZEB1 Collaborates with ELK3 to Repress E-Cadherin Expression in Triple-Negative Breast Cancer CellsZEB1 and ELK3 Complex Targets E-Cadherin in Breast Cancer. Molecular Cancer Research, 17(11), 2257-2266.

Yoo, S. M., Lee, C. J., An, H. J., Lee, J. Y., Lee, H. S., Kang, H. C., ... & Cho, Y. Y. (2019). RSK2-mediated ELK3 activation enhances cell transformation and breast cancer cell growth by regulation of c-fos promoter activity. International journal of molecular sciences, 20(8), 1994.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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