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Mouse Anti-EN1 Recombinant Antibody (4G11) (CBMAB-0227-CN)

This product is a mouse antibody that recognizes EN1 of chicken. The antibody 4G11 can be used for immunoassay techniques such as: IF, IHC.
See all EN1 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken, Zebrafish
Clone
4G11
Antibody Isotype
IgG1
Application
IF, IHC

Basic Information

Immunogen
Peptide: NFFIDNILRPDFG
Specificity
Chicken, Zebrafish
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EN1
Introduction
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal.
Entrez Gene ID
Chicken771008
Zebrafish30244
UniProt ID
ChickenA0A1D5PIQ4
ZebrafishQ68EL7
Alternative Names
En-1; en-3; Gg-En-1
Biological Process
Adult locomotory behavior Source: Ensembl
Anatomical structure morphogenesis Source: ProtInc
Cerebellum development Source: Ensembl
Dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Dorsal/ventral pattern formation Source: Ensembl
Drinking behavior Source: Ensembl
Embryonic brain development Source: Ensembl
Embryonic forelimb morphogenesis Source: Ensembl
Midbrain development Source: Ensembl
Midbrain-hindbrain boundary development Source: Ensembl
Motor learning Source: Ensembl
Multicellular organism growth Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Neuron development Source: Ensembl
Neuron differentiation Source: GO_Central
Pigmentation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Rregulation of transcription by RNA polymerase II Source: GO_Central
Response to cocaine Source: Ensembl
Skeletal system development Source: ProtInc
Social behavior Source: Ensembl
Cellular Location
Nucleus

Yang, L., Li, X., Luo, Y., Yang, T., Wang, H., Shi, L., ... & Xie, W. (2021). Weighted gene co‑expression network analysis of the association between upregulated AMD1, EN1 and VGLL1 and the progression and poor prognosis of breast cancer. Experimental and Therapeutic Medicine, 22(3), 1-13.

Baba, S., Akashi, T., Kayamori, K., Ohuchi, T., Ogawa, I., Kubota, N., ... & Ikeda, T. (2021). Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma. Pathology International, 71(2), 113-123.

Györfi, A. H., Matei, A. E., Fuchs, M., Liang, C., Rigau, A. R., Hong, X., ... & Distler, J. H. (2021). Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation. Journal of Experimental Medicine, 218(9), e20201916.

Miura, K., Akashi, T., Namiki, T., Hishima, T., Bae, Y., Sakurai, U., ... & Eishi, Y. (2020). Engrailed homeobox 1 and cytokeratin 19 are independent diagnostic markers of eccrine porocarcinoma and distinguish it from squamous cell carcinoma. American Journal of Clinical Pathology, 154(4), 499-509.

Zhu, J., & Zhang, Y. Q. (2019). Engrailed 1 overexpression as a potential prognostic marker in Lower Grade Glioma. PeerJ, 7, e7414.

Gandhi, N. S., Blancafort, P., & Mancera, R. L. (2018). Atomistic molecular dynamics simulations of bioactive engrailed 1 interference peptides (EN1-iPeps). Oncotarget, 9(32), 22383.

Miura, K., Akashi, T., Ando, N., Ayabe, S., Kayamori, K., Namiki, T., & Eishi, Y. (2018). Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. Histopathology, 72(7), 1199-1208.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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