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  • Rabbit Anti-EPHX2 Recombinant Antibody (CBFYE-1040)

Rabbit Anti-EPHX2 Recombinant Antibody (CBFYE-1040) (V2LY-0825-LY516)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
CBFYE-1040
Application
WB
Immunogen
Synthetic peptide within human ephx2 aa 1-50.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, glycerol, BSA
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Epoxide Hydrolase 2
Entrez Gene ID
2053
UniProt ID
P34913
Research Area
Bifunctional enzyme (PubMed:12574510).

The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687).

Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity).

Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101).

Bifunctional enzyme (PubMed:12574510).

The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510).

Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545).
Biological Process
Cholesterol homeostasis Source: UniProtKB
Dephosphorylation Source: UniProtKB
Epoxide metabolic process Source: UniProtKB
Phospholipid dephosphorylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Regulation of cholesterol metabolic process Source: UniProtKB
Response to toxic substance Source: UniProtKB-KW
Stilbene catabolic process Source: UniProtKB
Cellular Location
Cytoplasm; Peroxisome
PTM
The N-terminus is blocked.
The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable).

Roumeliotis, S., Roumeliotis, A., Stamou, A., Panagoutsos, S., Manolopoulos, V. G., Tsetsos, F., ... & Liakopoulos, V. (2021). Association of rs11780592 polymorphism in the human soluble epoxide hydrolase gene (EPHX2) with oxidized LDL and mortality in patients with diabetic chronic kidney disease. Oxidative medicine and cellular longevity, 2021.

Li, X., & Wu, X. (2021). Soluble epoxide hydrolase (Ephx2) silencing attenuates the hydrogen peroxide-induced oxidative damage in IEC-6 cells. Archives of Medical Science: AMS, 17(4), 1075.

Khadir, A., Kavalakatt, S., Madhu, D., Cherian, P., Al-Mulla, F., Abubaker, J., & Tiss, A. (2020). Soluble epoxide hydrolase 2 expression is elevated in obese humans and decreased by physical activity. International journal of molecular sciences, 21(6), 2056.

Demirdöğen, B. C., Miçooğulları, Y., Özçelik, A. T., & Adalı, O. (2020). Missense genetic polymorphisms of microsomal (EPHX1) and soluble epoxide hydrolase (EPHX2) and their relation to the risk of large artery atherosclerotic ischemic stroke in a Turkish population. Neuropsychiatric disease and treatment, 16, 3251.

Ma, L., Zhao, H., Yu, M., Wen, Y., Zhao, T., Yan, M., ... & Niu, W. (2020). Association of epoxide hydrolase 2 gene Arg287Gln with the risk for primary hypertension in Chinese. International journal of hypertension, 2020.

Sun, H., Lee, P., Yan, C., Gao, N., Wang, J., Fan, X., & Yu, F. S. (2018). Inhibition of soluble epoxide hydrolase 2 ameliorates diabetic keratopathy and impaired wound healing in mouse corneas. Diabetes, 67(6), 1162-1172.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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