Rabbit Anti-EPX Recombinant Antibody (E1620) (V2LY-0825-LY575)

Name: Rabbit Anti-EPX Recombinant Antibody (E1620)
SKU: V2LY-0825-LY575
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

E1620

Application

FC, IHC, IF

Immunogen

Human eosinophils.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	0.5-1 µg/ml
IHC-P	1-2 µg/ml
FC	0.5-1 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Eosinophil Peroxidase

Entrez Gene ID

8288

UniProt ID

P11678

Research Area

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Biological Process

Defense response to bacterium Source: GO_Central
Defense response to nematode Source: Ensembl
Eosinophil migration Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB-KW
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of interleukin-5 production Source: Ensembl
Positive regulation of interleukin-4 production Source: Ensembl
Response to oxidative stress Source: InterPro

Cellular Location

Cytoplasmic granule. Cytoplasmic granules of eosinophils.

Involvement in disease

Eosinophil peroxidase deficiency (EPXD):
A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.

Choi, K. M., Joo, M. S., Kang, G., Woo, W. S., Kim, K. H., Jeong, S. H., ... & Park, C. I. (2021). First report of eosinophil peroxidase in starry flounder (Platichthys stellatus): Gene identification and gene expression profiling. Fish & Shellfish Immunology, 118, 155-159.

Wright, B. L., Doyle, A. D., Shim, K. P., Pai, R. K., Barshow, S. M., Horsley-Silva, J. L., ... & Dellon, E. S. (2021). Image analysis of eosinophil peroxidase immunohistochemistry for diagnosis of eosinophilic esophagitis. Digestive diseases and sciences, 66(3), 775-783.

Germic, N., Fettrelet, T., Stojkov, D., Hosseini, A., Horn, M. P., Karaulov, A., ... & Simon, H. U. (2021). The release kinetics of eosinophil peroxidase and mitochondrial DNA is different in association with eosinophil extracellular trap formation. Cells, 10(2), 306.

Hasan, S. H., Taylor, S., Garg, S., Buras, M. R., Doyle, A. D., Bauer, C. S., ... & Schroeder, S. (2021). Diagnosis of pediatric non-esophageal eosinophilic gastrointestinal disorders by eosinophil peroxidase immunohistochemistry. Pediatric and Developmental Pathology, 24(6), 513-522.

Sánchez, J., Sánchez, A., Munera, M., Garcia, E., Lopez, J. F., Velásquez-Lopera, M., & Cardona, R. (2021). Presence of IgE autoantibodies against eosinophil peroxidase and eosinophil cationic protein in severe chronic spontaneous urticaria and atopic dermatitis. Allergy, asthma & immunology research, 13(5), 746.

Roth-Carter, Q. R., Luo, H., Ochkur, S. I., Jacobsen, E. A., Datena, M., Fryer, A. D., ... & Jacoby, D. B. (2020). Eosinophil peroxidase induces inflammation in a mouse model of dermatitis. bioRxiv.

Percopo, C. M., Krumholz, J. O., Fischer, E. R., Kraemer, L. S., Ma, M., Laky, K., & Rosenberg, H. F. (2019). Impact of eosinophil‐peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways. Journal of leukocyte biology, 105(1), 151-161.

Colon, S., Luan, H., Liu, Y., Meyer, C., Gewin, L., & Bhave, G. (2019). Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model. American Journal of Physiology-Renal Physiology, 316(2), F360-F371.

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., ... & Rank, M. A. (2019). Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 143(6), 2284-2287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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