EPX

This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]

Eosinophil Peroxidase

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Defense response to bacterium Source: GO_Central
Defense response to nematode Source: Ensembl
Eosinophil migration Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB-KW
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of interleukin-5 production Source: Ensembl
Positive regulation of interleukin-4 production Source: Ensembl
Response to oxidative stress Source: InterPro

Cytoplasmic granule. Cytoplasmic granules of eosinophils.

Eosinophil peroxidase deficiency (EPXD):
A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.