Human EPX ELISA Kit (V2LY-0626-LY3825)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.12 mU/mL
Detection Range
0.2-60 mU/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
81.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Eosinophil Peroxidase
Research Area
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Biological Process
Defense response to bacterium Source: GO_Central
Defense response to nematode Source: Ensembl
Eosinophil migration Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB-KW
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of interleukin-5 production Source: Ensembl
Positive regulation of interleukin-4 production Source: Ensembl
Response to oxidative stress Source: InterPro
Cellular Location
Cytoplasmic granule. Cytoplasmic granules of eosinophils.
Involvement in disease
Eosinophil peroxidase deficiency (EPXD):
A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.

Choi, K. M., Joo, M. S., Kang, G., Woo, W. S., Kim, K. H., Jeong, S. H., ... & Park, C. I. (2021). First report of eosinophil peroxidase in starry flounder (Platichthys stellatus): Gene identification and gene expression profiling. Fish & Shellfish Immunology, 118, 155-159.

Wright, B. L., Doyle, A. D., Shim, K. P., Pai, R. K., Barshow, S. M., Horsley-Silva, J. L., ... & Dellon, E. S. (2021). Image analysis of eosinophil peroxidase immunohistochemistry for diagnosis of eosinophilic esophagitis. Digestive diseases and sciences, 66(3), 775-783.

Germic, N., Fettrelet, T., Stojkov, D., Hosseini, A., Horn, M. P., Karaulov, A., ... & Simon, H. U. (2021). The release kinetics of eosinophil peroxidase and mitochondrial DNA is different in association with eosinophil extracellular trap formation. Cells, 10(2), 306.

Hasan, S. H., Taylor, S., Garg, S., Buras, M. R., Doyle, A. D., Bauer, C. S., ... & Schroeder, S. (2021). Diagnosis of pediatric non-esophageal eosinophilic gastrointestinal disorders by eosinophil peroxidase immunohistochemistry. Pediatric and Developmental Pathology, 24(6), 513-522.

Sánchez, J., Sánchez, A., Munera, M., Garcia, E., Lopez, J. F., Velásquez-Lopera, M., & Cardona, R. (2021). Presence of IgE autoantibodies against eosinophil peroxidase and eosinophil cationic protein in severe chronic spontaneous urticaria and atopic dermatitis. Allergy, asthma & immunology research, 13(5), 746.

Roth-Carter, Q. R., Luo, H., Ochkur, S. I., Jacobsen, E. A., Datena, M., Fryer, A. D., ... & Jacoby, D. B. (2020). Eosinophil peroxidase induces inflammation in a mouse model of dermatitis. bioRxiv.

Percopo, C. M., Krumholz, J. O., Fischer, E. R., Kraemer, L. S., Ma, M., Laky, K., & Rosenberg, H. F. (2019). Impact of eosinophil‐peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways. Journal of leukocyte biology, 105(1), 151-161.

Colon, S., Luan, H., Liu, Y., Meyer, C., Gewin, L., & Bhave, G. (2019). Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model. American Journal of Physiology-Renal Physiology, 316(2), F360-F371.

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., ... & Rank, M. A. (2019). Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 143(6), 2284-2287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Epx ELISA Kit (CAT#: V2LY-0626-LY2339)

Related Products

Rabbit Anti-EPX Recombinant Antibody (E1620) (CAT#: V2LY-0825-LY575)

Mouse Anti-EPX Recombinant Antibody (EPO104) (CAT#: V2LY-0825-LY577)

Mouse Epx ELISA Kit (CAT#: V2LY-0626-LY2339)

Mouse Anti-EPX Recombinant Antibody (E0260) (CAT#: V2LY-0825-LY576)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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