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Mouse Anti-ESR2 Recombinant Antibody (28) (CBMAB-1187-YC)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
28
Application
IP, WB
Immunogen
Amino acids 1-153 of human ESR2 expressed in E. coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1-5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Estrogen Receptor 2
Introduction
ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. ESR2 is localized to the nucleus, cytoplasm, and mitochondria. ESR2 forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription.
Entrez Gene ID
2100
UniProt ID
Q92731
Alternative Names
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
Research Area
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).

Isoform 2:
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular response to estradiol stimulus Source: CAFA
Intracellular estrogen receptor signaling pathway Source: CAFA
Intracellular steroid hormone receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: CAFA
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Ovarian dysgenesis 8 (ODG8):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
PTM
Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.

Dalal, H., Dahlgren, M., Gladchuk, S., Brueffer, C., Gruvberger-Saal, S. K., & Saal, L. H. (2022). Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors. Scientific reports, 12(1), 1-12.

He, J., Yan, J. J., Zha, X., Ding, X. J., Zhang, Y. L., Lu, Z., & Xu, X. H. (2022). Sexually dimorphic effects of estrogen receptor 2 deletion in the dorsal raphe nucleus on emotional behaviors. Journal of Neuroendocrinology, e13195.

Asiamah, C. A., Liu, Y., Ye, R., Pan, Y., Lu, L. L., Zou, K., ... & Su, Y. (2022). Polymorphism analysis and expression profile of the estrogen receptor 2 gene in Leizhou black duck. Poultry Science, 101(3), 101630.

Gregorio, K. C. R., Laurindo, C. P., & Machado, U. F. (2021). Estrogen and glycemic homeostasis: the fundamental role of nuclear estrogen receptors ESR1/ESR2 in glucose transporter GLUT4 regulation. Cells, 10(1), 99.

Ulhaq, Z. S., & Garcia, C. P. (2021). Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia. Acta Neurologica Belgica, 121(5), 1281-1293.

Chmielewska, M., Janusz, P., Andrusiewicz, M., Kotwicki, T., & Kotwicka, M. (2020). Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis. Scientific reports, 10(1), 1-14.

Bahia, W., Soltani, I., Haddad, A., Soua, A., Radhouani, A., Mahdhi, A., & Ferchichi, S. (2020). Association of genetic variants in Estrogen receptor (ESR) 1 and ESR2 with susceptibility to recurrent pregnancy loss in Tunisian women: A case control study. Gene, 736, 144406.

Lang-Muritano, M., Sproll, P., Wyss, S., Kolly, A., Hürlimann, R., Konrad, D., & Biason-Lauber, A. (2018). Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor β (ESR2). The Journal of Clinical Endocrinology & Metabolism, 103(10), 3748-3756.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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