ESR2

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Full Name
Estrogen Receptor 2
Research Area
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).

Isoform 2:
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular response to estradiol stimulus Source: CAFA
Intracellular estrogen receptor signaling pathway Source: CAFA
Intracellular steroid hormone receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: CAFA
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Ovarian dysgenesis 8 (ODG8):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
PTM
Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
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Anti-ESR2 antibodies

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Mouse Anti-ESR2 Recombinant Antibody (55) (CBMAB-E1881-FY)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 55
Application*: WB, E
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (686) (CBMAB-AP2151LY)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 686
Application*: IF
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1285) (CBMAB-E1876-FY)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-1285
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-0117) (CBMAB-E0237-FY)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0117
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (7B10) (CBMAB-E1884-FY)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 7B10
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (10) (CBMAB-O0168-CQ)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10
Application*: WB
Datasheet SDS

Human Anti-ESR2 Recombinant Antibody (455) (CBMAB-1217-YC)

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Target: ESR2
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: 455
Application*: WB, E
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (6A12) (CBMAB-1188-YC)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A12
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (28) (CBMAB-1187-YC)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 28
Application*: IP, WB
Datasheet SDS

Mouse Anti-ESR2 Recombinant Antibody (3F3) (V2LY-0825-LY799)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F3
Application*: WB, E, IF
Datasheet SDS

Rabbit Anti-ESR2 Recombinant Antibody (CBFYE-1284) (V2LY-0825-LY797)

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Target: ESR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1284
Application*: IH, WB
Datasheet SDS

Rabbit Anti-ESR2 Recombinant Antibody (1216) (V2LY-0825-LY791)

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Target: ESR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1216
Application*: P, WB
Datasheet SDS

Mouse Anti-ESR2 Monoclonal Antibody (CWK-F12) (CBMAB-1212CQ)

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Target: ESR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Pig, Rat
Clone: CWK-F12
Application*: IP, E, B, IF, IH, WB
Functional Assay
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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