Mouse Anti-ESR2 Recombinant Antibody (3F3) (V2LY-0825-LY799)

Name: Mouse Anti-ESR2 Recombinant Antibody (3F3)
SKU: V2LY-0825-LY799
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F3

Application

WB, ELISA, IF

Immunogen

ESR2 (aa 22-121) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Estrogen Receptor 2

Entrez Gene ID

2100

UniProt ID

Q92731

Research Area

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).

Isoform 2:
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to estradiol stimulus Source: CAFA
Intracellular estrogen receptor signaling pathway Source: CAFA
Intracellular steroid hormone receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: CAFA
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Ovarian dysgenesis 8 (ODG8):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.

PTM

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.

Dalal, H., Dahlgren, M., Gladchuk, S., Brueffer, C., Gruvberger-Saal, S. K., & Saal, L. H. (2022). Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors. Scientific reports, 12(1), 1-12.

He, J., Yan, J. J., Zha, X., Ding, X. J., Zhang, Y. L., Lu, Z., & Xu, X. H. (2022). Sexually dimorphic effects of estrogen receptor 2 deletion in the dorsal raphe nucleus on emotional behaviors. Journal of Neuroendocrinology, e13195.

Asiamah, C. A., Liu, Y., Ye, R., Pan, Y., Lu, L. L., Zou, K., ... & Su, Y. (2022). Polymorphism analysis and expression profile of the estrogen receptor 2 gene in Leizhou black duck. Poultry Science, 101(3), 101630.

Gregorio, K. C. R., Laurindo, C. P., & Machado, U. F. (2021). Estrogen and glycemic homeostasis: the fundamental role of nuclear estrogen receptors ESR1/ESR2 in glucose transporter GLUT4 regulation. Cells, 10(1), 99.

Ulhaq, Z. S., & Garcia, C. P. (2021). Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia. Acta Neurologica Belgica, 121(5), 1281-1293.

Chmielewska, M., Janusz, P., Andrusiewicz, M., Kotwicki, T., & Kotwicka, M. (2020). Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis. Scientific reports, 10(1), 1-14.

Bahia, W., Soltani, I., Haddad, A., Soua, A., Radhouani, A., Mahdhi, A., & Ferchichi, S. (2020). Association of genetic variants in Estrogen receptor (ESR) 1 and ESR2 with susceptibility to recurrent pregnancy loss in Tunisian women: A case control study. Gene, 736, 144406.

Lang-Muritano, M., Sproll, P., Wyss, S., Kolly, A., Hürlimann, R., Konrad, D., & Biason-Lauber, A. (2018). Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor β (ESR2). The Journal of Clinical Endocrinology & Metabolism, 103(10), 3748-3756.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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