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Mouse Anti-EXOSC4 Recombinant Antibody (4F9) (CBMAB-A2758-LY)

The product is antibody recognizes EXOSC4. The antibody 4F9 immunoassay techniques such as: WB, ELISA.
See all EXOSC4 antibodies
Published Data
Fig.1 RNA–protein complexes were detected by gel-shift analysis on 5% native acrylamide gels.
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Fig.2 Proteins were analyzed by SDS-PAGE followed by staining with Coomassie blue.
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Fig.3 Western blotting result using this antibody.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EXOSC4 (NP_061910.1, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
exosome component 4
Entrez Gene ID
54512
UniProt ID
Q9NPD3
Alternative Names
FLJ20591; RRP41; RRP41A; Rrp41p; SKI6; Ski6p; hRrp41p; p12A
Research Area
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Biological Process
Defense response to virus Source: MGI
DNA deamination Source: UniProtKB
Histone mRNA catabolic process Source: UniProtKB
Maturation of 5.8S rRNA Source: UniProtKB
Nuclear mRNA surveillance Source: UniProtKB
Nuclear-transcribed mRNA catabolic process Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: GO_Central
Polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
Positive regulation of cell growth Source: UniProtKB
rRNA catabolic process Source: GO_Central
rRNA processing Source: UniProtKB
U4 snRNA 3'-end processing Source: GO_Central
Cellular Location
Nucleolus; Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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