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Mouse Anti-FAM19A4 Recombinant Antibody (CBYJT-1277) (CBMAB-T0292-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to FAM19A4 (Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like). The antibody can be used for immunoassay techniques, such as WB, ICFC, CyTOF.
See all FAM19A4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1277
Antibody Isotype
IgG1
Application
WB, ICFC, CyTOF

Basic Information

Immunogen
E. coli-derived recombinant human TAFA4, Ser35-Arg140, Accession # Q96LR4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 35-140

Target

Full Name
Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like
Introduction
FAM19A4 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.
Entrez Gene ID
151647
UniProt ID
Q96LR4
Alternative Names
Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like; Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A4; Chemokine-Like Protein TAFA-4; TAFA4; Protein FAM19A4; TAFA-4
Research Area
Modulates injury-induced and chemical pain hypersensitivity (By similarity).

Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).
Biological Process
Macrophage chemotaxis Source: UniProtKB
Phagocytosis Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Regulation of sensory perception of pain Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Superoxide anion generation Source: UniProtKB
Cellular Location
Secreted

van Trommel, N., Kremer, W., Dick, S., Heideman, D., Steenbergen, R., Bleeker, M., ... & Berkhof, J. (2022). 2022-RA-1253-ESGO CONCERVE study demonstrates that clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124–2 DNA methylation.

Kremer, W. W., Dick, S., Heideman, D. A., Steenbergen, R. D., Bleeker, M. C., Verhoeve, H. R., ... & Berkhof, J. (2022). Clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124-2 DNA methylation (CONCERVE study). Journal of Clinical Oncology, 40(26), 3037-3046.

Hampl, M., Hesselink, B., Meijer, C., Denecke, A., Einhorn, I., Jentschke, M., ... & Hillemanns, P. (2022). 2022-RA-1264-ESGO Evaluation of managing CIN 3 plus diagnosed pregnant women by methylation assessment using FAM19A4/miR124 methylation test.

Dick, S., Vink, F. J., Heideman, D. A., Lissenberg-Witte, B. I., Meijer, C. J., & Berkhof, J. (2022). Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping. British journal of cancer, 126(2), 259-264.

Bonde, J., Floore, A., Ejegod, D., Vink, F. J., Hesselink, A., van de Ven, P. M., ... & Heideman, D. A. (2021). Methylation markers FAM19A4 and miR124‐2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study. International journal of cancer, 148(2), 396-405.

Vink, F. J., Dick, S., Heideman, D. A., De Strooper, L. M., Steenbergen, R. D., Lissenberg‐Witte, B. I., ... & Meijer, C. J. (2021). Classification of high‐grade cervical intraepithelial neoplasia by p16ink4a, Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management. International Journal of Cancer, 149(3), 707-716.

Vink, F. J., Meijer, C. J., Clifford, G. M., Poljak, M., Oštrbenk, A., Petry, K. U., ... & Heideman, D. A. (2020). FAM19A4/miR124‐2 methylation in invasive cervical cancer: a retrospective cross‐sectional worldwide study. International Journal of Cancer, 147(4), 1215-1221.

Dick, S., Kremer, W. W., De Strooper, L. M., Lissenberg-Witte, B. I., Steenbergen, R. D., Meijer, C. J., ... & Heideman, D. A. (2019). Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis. Gynecologic Oncology, 154(2), 368-373.

De Strooper, L. M., Berkhof, J., Steenbergen, R. D., Lissenberg‐Witte, B. I., Snijders, P. J., Meijer, C. J., & Heideman, D. A. (2018). Cervical cancer risk in HPV‐positive women after a negative FAM19A4/mir124‐2 methylation test: a post hoc analysis in the POBASCAM trial with 14 year follow‐up. International Journal of Cancer, 143(6), 1541-1548.

Bu, Q., Wang, S., Ma, J., Zhou, X., Hu, G., Deng, H., ... & Luo, X. (2018). The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre) cancer in Chinese women. BMC cancer, 18(1), 1-10.

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For research use only. Not intended for any clinical use.

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