Mouse Anti-FAM19A4 Recombinant Antibody (CBYJT-1277) (CBMAB-T0292-YJ)

Name: Mouse Anti-FAM19A4 Recombinant Antibody (CBYJT-1277)
SKU: CBMAB-T0292-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-1277

Application

WB, FC

Immunogen

E. coli-derived recombinant human TAFA4 (Ser35-Arg140).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 μg/ml
FC	2.5 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Epitope

aa 35-140

More Infomation

Target

Full Name

Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like

Introduction

FAM19A4 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.

Entrez Gene ID

151647

UniProt ID

Q96LR4

Alternative Names

Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like; Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A4; Chemokine-Like Protein TAFA-4; TAFA4; Protein FAM19A4; TAFA-4

Research Area

Modulates injury-induced and chemical pain hypersensitivity (By similarity).

Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).

Biological Process

Macrophage chemotaxis Source: UniProtKB
Phagocytosis Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Regulation of sensory perception of pain Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Superoxide anion generation Source: UniProtKB

Cellular Location

Secreted

van Trommel, N., Kremer, W., Dick, S., Heideman, D., Steenbergen, R., Bleeker, M., ... & Berkhof, J. (2022). 2022-RA-1253-ESGO CONCERVE study demonstrates that clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124–2 DNA methylation.

Kremer, W. W., Dick, S., Heideman, D. A., Steenbergen, R. D., Bleeker, M. C., Verhoeve, H. R., ... & Berkhof, J. (2022). Clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124-2 DNA methylation (CONCERVE study). Journal of Clinical Oncology, 40(26), 3037-3046.

Hampl, M., Hesselink, B., Meijer, C., Denecke, A., Einhorn, I., Jentschke, M., ... & Hillemanns, P. (2022). 2022-RA-1264-ESGO Evaluation of managing CIN 3 plus diagnosed pregnant women by methylation assessment using FAM19A4/miR124 methylation test.

Dick, S., Vink, F. J., Heideman, D. A., Lissenberg-Witte, B. I., Meijer, C. J., & Berkhof, J. (2022). Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping. British journal of cancer, 126(2), 259-264.

Bonde, J., Floore, A., Ejegod, D., Vink, F. J., Hesselink, A., van de Ven, P. M., ... & Heideman, D. A. (2021). Methylation markers FAM19A4 and miR124‐2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study. International journal of cancer, 148(2), 396-405.

Vink, F. J., Dick, S., Heideman, D. A., De Strooper, L. M., Steenbergen, R. D., Lissenberg‐Witte, B. I., ... & Meijer, C. J. (2021). Classification of high‐grade cervical intraepithelial neoplasia by p16ink4a, Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management. International Journal of Cancer, 149(3), 707-716.

Vink, F. J., Meijer, C. J., Clifford, G. M., Poljak, M., Oštrbenk, A., Petry, K. U., ... & Heideman, D. A. (2020). FAM19A4/miR124‐2 methylation in invasive cervical cancer: a retrospective cross‐sectional worldwide study. International Journal of Cancer, 147(4), 1215-1221.

Dick, S., Kremer, W. W., De Strooper, L. M., Lissenberg-Witte, B. I., Steenbergen, R. D., Meijer, C. J., ... & Heideman, D. A. (2019). Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis. Gynecologic Oncology, 154(2), 368-373.

De Strooper, L. M., Berkhof, J., Steenbergen, R. D., Lissenberg‐Witte, B. I., Snijders, P. J., Meijer, C. J., & Heideman, D. A. (2018). Cervical cancer risk in HPV‐positive women after a negative FAM19A4/mir124‐2 methylation test: a post hoc analysis in the POBASCAM trial with 14 year follow‐up. International Journal of Cancer, 143(6), 1541-1548.

Bu, Q., Wang, S., Ma, J., Zhou, X., Hu, G., Deng, H., ... & Luo, X. (2018). The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre) cancer in Chinese women. BMC cancer, 18(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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