FAM19A4

FAM19A4 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.

Full Name

Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like

Research Area

Modulates injury-induced and chemical pain hypersensitivity (By similarity).

Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).

Biological Process

Macrophage chemotaxis Source: UniProtKB
Phagocytosis Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Regulation of sensory perception of pain Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Superoxide anion generation Source: UniProtKB

Cellular Location

Secreted