Human Recombinant FAM19A4 protein, hFc Tag (V2LY-0526-LY4002)

Name: Human Recombinant FAM19A4 protein, hFc Tag
SKU: V2LY-0526-LY4002
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant FAM19A4 protein, hFc Tag consist of Amino Acid: 36-140 and predicts a molecular mass of 40.1 kDa.

Molecule Mass

40.1 kDa

Sequence

Amino Acid: 36-140

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like

Research Area

Modulates injury-induced and chemical pain hypersensitivity (By similarity).

Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).

Biological Process

Macrophage chemotaxis Source: UniProtKB
Phagocytosis Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Regulation of sensory perception of pain Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Superoxide anion generation Source: UniProtKB

Cellular Location

Secreted

van Trommel, N., Kremer, W., Dick, S., Heideman, D., Steenbergen, R., Bleeker, M., ... & Berkhof, J. (2022). 2022-RA-1253-ESGO CONCERVE study demonstrates that clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124–2 DNA methylation.

Kremer, W. W., Dick, S., Heideman, D. A., Steenbergen, R. D., Bleeker, M. C., Verhoeve, H. R., ... & Berkhof, J. (2022). Clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4/miR124-2 DNA methylation (CONCERVE study). Journal of Clinical Oncology, 40(26), 3037-3046.

Hampl, M., Hesselink, B., Meijer, C., Denecke, A., Einhorn, I., Jentschke, M., ... & Hillemanns, P. (2022). 2022-RA-1264-ESGO Evaluation of managing CIN 3 plus diagnosed pregnant women by methylation assessment using FAM19A4/miR124 methylation test.

Dick, S., Vink, F. J., Heideman, D. A., Lissenberg-Witte, B. I., Meijer, C. J., & Berkhof, J. (2022). Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping. British journal of cancer, 126(2), 259-264.

Bonde, J., Floore, A., Ejegod, D., Vink, F. J., Hesselink, A., van de Ven, P. M., ... & Heideman, D. A. (2021). Methylation markers FAM19A4 and miR124‐2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study. International journal of cancer, 148(2), 396-405.

Vink, F. J., Dick, S., Heideman, D. A., De Strooper, L. M., Steenbergen, R. D., Lissenberg‐Witte, B. I., ... & Meijer, C. J. (2021). Classification of high‐grade cervical intraepithelial neoplasia by p16ink4a, Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management. International Journal of Cancer, 149(3), 707-716.

Vink, F. J., Meijer, C. J., Clifford, G. M., Poljak, M., Oštrbenk, A., Petry, K. U., ... & Heideman, D. A. (2020). FAM19A4/miR124‐2 methylation in invasive cervical cancer: a retrospective cross‐sectional worldwide study. International Journal of Cancer, 147(4), 1215-1221.

Dick, S., Kremer, W. W., De Strooper, L. M., Lissenberg-Witte, B. I., Steenbergen, R. D., Meijer, C. J., ... & Heideman, D. A. (2019). Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis. Gynecologic Oncology, 154(2), 368-373.

De Strooper, L. M., Berkhof, J., Steenbergen, R. D., Lissenberg‐Witte, B. I., Snijders, P. J., Meijer, C. J., & Heideman, D. A. (2018). Cervical cancer risk in HPV‐positive women after a negative FAM19A4/mir124‐2 methylation test: a post hoc analysis in the POBASCAM trial with 14 year follow‐up. International Journal of Cancer, 143(6), 1541-1548.

Bu, Q., Wang, S., Ma, J., Zhou, X., Hu, G., Deng, H., ... & Luo, X. (2018). The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre) cancer in Chinese women. BMC cancer, 18(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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