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Mouse Anti-FBLN2 Recombinant Antibody (2A2) (CBMAB-A2865-LY)

The product is antibody recognizes FBLN2. The antibody 2A2 immunoassay techniques such as: sELISA, ELISA.
See all FBLN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A2
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
FBLN2 (NP_001989, 1076 a.a. ~ 1184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibulin 2
Introduction
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Entrez Gene ID
UniProt ID
Research Area
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Biological Process
Extracellular matrix organization Source: InterPro
Positive regulation of cell-substrate adhesion Source: GO_Central
Cellular Location
Extracellular matrix
PTM
O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.

Balog, S., Fujiwara, R., Pan, S. Q., El‐Baradie, K. B., Choi, H. Y., Sinha, S., ... & Tsukamoto, H. (2022). Emergence of highly profibrotic and proinflammatory Lrat+ Fbln2+ HSC subpopulation in alcoholic hepatitis. Hepatology.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Correction to: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Medicine, 13.

Shen, Z., & Li, H. (2021). Long non-coding RNA GAS5 knockdown facilitates proliferation and impedes apoptosis by regulating miR-128-3p/FBLN2 axis in ox-LDL-induced THP-1 cells. Clinical Hemorheology and Microcirculation, 77(2), 153-164.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome medicine, 13(1), 1-18.

Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., ... & Melotte, V. (2021). Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO reports, 22(6), e51913.

Li, W. M., Chan, T. C., Huang, S. K. H., Wu, W. J., Ke, H. L., Liang, P. I., ... & Li, C. F. (2020). Prognostic utility of FBLN2 expression in patients with urothelial carcinoma. Frontiers in Oncology, 10, 570340.

Tang, C. Z., Yang, J. T., Liu, Q. H., Wang, Y. R., & Wang, W. S. (2019). Up‐regulated miR‐192‐5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2‐mediated TGF‐β1 signaling pathway. The FASEB Journal, 33(1), 606-618.

Davila, N., Hernandez, L. F., Corredor, C., Perez-Vazquez, J. F. F., Soberón, S., Enriquez, A., ... & Quiroz-Mercado, H. (2018). Expression levels of Fibulin-2 (Fbln2) and Fibulin-5 (Fbln5) on subretinal fluid in human primary rhegmatogenous retinal detachment. Investigative Ophthalmology & Visual Science, 59(9), 4225-4225.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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