FBLN2
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Full Name
Fibulin 2
Research Area
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Biological Process
Extracellular matrix organization Source: InterPro
Positive regulation of cell-substrate adhesion Source: GO_Central
Positive regulation of cell-substrate adhesion Source: GO_Central
Cellular Location
Extracellular matrix
PTM
O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.
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Anti-FBLN2 antibodies
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Target: FBLN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 22
Application*: WB, IP, E
Target: FBLN2
Sensitivity: 0.14 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: FBLN2
Sensitivity: 0.05 ng/mL
Detection Range: 0.1-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT540
Application*: WB, E
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4695
Application*: WB
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: EG1183
Application*: WB, IP, E
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1578
Application*: WB, IP, IF, E
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: CBXF-3582
Application*: WB, IP, IF, E
Target: FBLN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 18
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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