Human FBLN2 ELISA Kit (2) (V2LY-0626-LY4577)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.14 ng/mL
Detection Range
0.3-90 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
126.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Fibulin 2
Research Area
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Biological Process
Extracellular matrix organization Source: InterPro
Positive regulation of cell-substrate adhesion Source: GO_Central
Cellular Location
Extracellular matrix
PTM
O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.

Balog, S., Fujiwara, R., Pan, S. Q., El‐Baradie, K. B., Choi, H. Y., Sinha, S., ... & Tsukamoto, H. (2022). Emergence of highly profibrotic and proinflammatory Lrat+ Fbln2+ HSC subpopulation in alcoholic hepatitis. Hepatology.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Correction to: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Medicine, 13.

Shen, Z., & Li, H. (2021). Long non-coding RNA GAS5 knockdown facilitates proliferation and impedes apoptosis by regulating miR-128-3p/FBLN2 axis in ox-LDL-induced THP-1 cells. Clinical Hemorheology and Microcirculation, 77(2), 153-164.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome medicine, 13(1), 1-18.

Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., ... & Melotte, V. (2021). Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO reports, 22(6), e51913.

Li, W. M., Chan, T. C., Huang, S. K. H., Wu, W. J., Ke, H. L., Liang, P. I., ... & Li, C. F. (2020). Prognostic utility of FBLN2 expression in patients with urothelial carcinoma. Frontiers in Oncology, 10, 570340.

Tang, C. Z., Yang, J. T., Liu, Q. H., Wang, Y. R., & Wang, W. S. (2019). Up‐regulated miR‐192‐5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2‐mediated TGF‐β1 signaling pathway. The FASEB Journal, 33(1), 606-618.

Davila, N., Hernandez, L. F., Corredor, C., Perez-Vazquez, J. F. F., Soberón, S., Enriquez, A., ... & Quiroz-Mercado, H. (2018). Expression levels of Fibulin-2 (Fbln2) and Fibulin-5 (Fbln5) on subretinal fluid in human primary rhegmatogenous retinal detachment. Investigative Ophthalmology & Visual Science, 59(9), 4225-4225.

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For research use only. Not intended for any clinical use.

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