Mouse Anti-FPR2 (ASWGGTPEERLKC) Recombinant Antibody (CBXF-2417) (CBMAB-F1355-CQ)

Name: Mouse Anti-FPR2 (ASWGGTPEERLKC) Recombinant Antibody (CBXF-2417)
SKU: CBMAB-F1355-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2417

Application

ELISA, WB

Immunogen

The peptide (ASWGGTPEERLKC) from the 2nd extracellular loop of human FPRL1

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in 0.01 M PBS pH7.2

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

ASWGGTPEERLKC

More Infomation

Target

Full Name

Formyl Peptide Receptor 2

Introduction

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Prion Disease. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.

Entrez Gene ID

2358

UniProt ID

P25090

Alternative Names

Formyl Peptide Receptor 2; Formyl Peptide Receptor-Like 1; FMLP-Related Receptor I; LXA4 Receptor; FMLP-R-I; FPRL1; FPRH1; LXA4R; HM63; RFP;

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236).

Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236).

The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339).

Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Acts as a receptor for humanin (PubMed:15465011).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Astrocyte activation Source: ARUK-UCL
Calcium-mediated signaling Source: ARUK-UCL
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ARUK-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
Defense response to bacterium Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: ARUK-UCL
Immune response-regulating cell surface receptor signaling pathway Source: ARUK-UCL
Inflammatory response Source: GO_Central
Microglial cell activation Source: ARUK-UCL
Negative regulation of inflammatory response Source: ARUK-UCL
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive chemotaxis Source: ARUK-UCL
Positive regulation of 1-phosphatidylinositol-3-kinase activity Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of innate immune response Source: ARUK-UCL
Positive regulation of monocyte chemotaxis Source: ARUK-UCL
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Cellular Location

Cell membrane. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011).

Topology

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-351

Lee, C., Han, J., & Jung, Y. (2023). Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver. Experimental & Molecular Medicine, 1-8.

Lupisella, J. A., Shirude, P. S., Wurtz, N. R., & Garcia, R. A. (2022, March). Formyl peptide receptor 2 and heart disease. In Seminars in Immunology (p. 101602). Academic Press.

Qin, C. X., Norling, L. V., Vecchio, E. A., Brennan, E. P., May, L. T., Wootten, D., ... & Ritchie, R. H. (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. British Journal of Pharmacology, 179(19), 4617-4639.

Zhuang, Y., Wang, L., Guo, J., Sun, D., Wang, Y., Liu, W., ... & Zhang, C. (2022). Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nature communications, 13(1), 1054.

Maciuszek, M., Cacace, A., Brennan, E., Godson, C., & Chapman, T. M. (2021). Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. European Journal of Medicinal Chemistry, 213, 113167.

Trojan, E., Tylek, K., Leśkiewicz, M., Lasoń, W., Brandenburg, L. O., Leopoldo, M., ... & Basta-Kaim, A. (2021). The N-Formyl Peptide Receptor 2 (FPR2) agonist MR-39 exhibits anti-inflammatory activity in LPS-stimulated organotypic hippocampal cultures. Cells, 10(6), 1524.

das Dores Pereira, R., Rabelo, R. A. N., Leite, P. G., Cramer, A., Botelho, A. F. M., Cruz, J. S., ... & Machado, F. S. (2021). Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease. Cellular immunology, 369, 104427.

Trojan, E., Tylek, K., Schröder, N., Kahl, I., Brandenburg, L. O., Mastromarino, M., ... & Lacivita, E. (2021). The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease. Molecular Neurobiology, 58(12), 6203-6221.

Asahina, Y., Wurtz, N. R., Arakawa, K., Carson, N., Fujii, K., Fukuchi, K., ... & Kohno, Y. (2020). Discovery of BMS-986235/LAR-1219: a potent formyl peptide receptor 2 (FPR2) selective agonist for the prevention of heart failure. Journal of Medicinal Chemistry, 63(17), 9003-9019.

Chen, T., Xiong, M., Zong, X., Ge, Y., Zhang, H., Wang, M., ... & Wu, B. (2020). Structural basis of ligand binding modes at the human formyl peptide receptor 2. Nature communications, 11(1), 1208.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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