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Mouse Anti-FPR2 Recombinant Antibody (2D8) (CBMAB-A3165-LY)

The product is antibody recognizes FPR2. The antibody 2D8 immunoassay techniques such as: WB, ELISA.
See all FPR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FPR2 (AAH29125.1, 163 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Formyl Peptide Receptor 2
Entrez Gene ID
2358
UniProt ID
P25090
Alternative Names
ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236).

Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236).

The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339).

Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Acts as a receptor for humanin (PubMed:15465011).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Astrocyte activation Source: ARUK-UCL
Calcium-mediated signaling Source: ARUK-UCL
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ARUK-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
Defense response to bacterium Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: ARUK-UCL
Immune response-regulating cell surface receptor signaling pathway Source: ARUK-UCL
Inflammatory response Source: GO_Central
Microglial cell activation Source: ARUK-UCL
Negative regulation of inflammatory response Source: ARUK-UCL
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive chemotaxis Source: ARUK-UCL
Positive regulation of 1-phosphatidylinositol-3-kinase activity Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of innate immune response Source: ARUK-UCL
Positive regulation of monocyte chemotaxis Source: ARUK-UCL
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Cellular Location
Cell membrane. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011).
Topology
Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-351

Lee, C., Han, J., & Jung, Y. (2023). Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver. Experimental & Molecular Medicine, 1-8.

Lupisella, J. A., Shirude, P. S., Wurtz, N. R., & Garcia, R. A. (2022, March). Formyl peptide receptor 2 and heart disease. In Seminars in Immunology (p. 101602). Academic Press.

Qin, C. X., Norling, L. V., Vecchio, E. A., Brennan, E. P., May, L. T., Wootten, D., ... & Ritchie, R. H. (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. British Journal of Pharmacology, 179(19), 4617-4639.

Zhuang, Y., Wang, L., Guo, J., Sun, D., Wang, Y., Liu, W., ... & Zhang, C. (2022). Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nature communications, 13(1), 1054.

Maciuszek, M., Cacace, A., Brennan, E., Godson, C., & Chapman, T. M. (2021). Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. European Journal of Medicinal Chemistry, 213, 113167.

Trojan, E., Tylek, K., Leśkiewicz, M., Lasoń, W., Brandenburg, L. O., Leopoldo, M., ... & Basta-Kaim, A. (2021). The N-Formyl Peptide Receptor 2 (FPR2) agonist MR-39 exhibits anti-inflammatory activity in LPS-stimulated organotypic hippocampal cultures. Cells, 10(6), 1524.

das Dores Pereira, R., Rabelo, R. A. N., Leite, P. G., Cramer, A., Botelho, A. F. M., Cruz, J. S., ... & Machado, F. S. (2021). Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease. Cellular immunology, 369, 104427.

Trojan, E., Tylek, K., Schröder, N., Kahl, I., Brandenburg, L. O., Mastromarino, M., ... & Lacivita, E. (2021). The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease. Molecular Neurobiology, 58(12), 6203-6221.

Asahina, Y., Wurtz, N. R., Arakawa, K., Carson, N., Fujii, K., Fukuchi, K., ... & Kohno, Y. (2020). Discovery of BMS-986235/LAR-1219: a potent formyl peptide receptor 2 (FPR2) selective agonist for the prevention of heart failure. Journal of Medicinal Chemistry, 63(17), 9003-9019.

Chen, T., Xiong, M., Zong, X., Ge, Y., Zhang, H., Wang, M., ... & Wu, B. (2020). Structural basis of ligand binding modes at the human formyl peptide receptor 2. Nature communications, 11(1), 1208.

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For research use only. Not intended for any clinical use.

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