FPR2

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Prion Disease. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.

Full Name

Formyl Peptide Receptor 2

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236).

Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236).

The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339).

Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Acts as a receptor for humanin (PubMed:15465011).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Astrocyte activation Source: ARUK-UCL
Calcium-mediated signaling Source: ARUK-UCL
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ARUK-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
Defense response to bacterium Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: ARUK-UCL
Immune response-regulating cell surface receptor signaling pathway Source: ARUK-UCL
Inflammatory response Source: GO_Central
Microglial cell activation Source: ARUK-UCL
Negative regulation of inflammatory response Source: ARUK-UCL
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive chemotaxis Source: ARUK-UCL
Positive regulation of 1-phosphatidylinositol-3-kinase activity Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of innate immune response Source: ARUK-UCL
Positive regulation of monocyte chemotaxis Source: ARUK-UCL
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Cellular Location

Cell membrane. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011).

Topology

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-351