Mouse Anti-FRMD5 Recombinant Antibody (CBXF-1798) (CBMAB-F3333-CQ)

This product is a mouse antibody that recognizes FRMD5. The antibody CBXF-1798 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FRMD5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-1798

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

FERM Domain Containing 5

Introduction

FRMD5 (FERM Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is FRMD3.

Entrez Gene ID

84978

UniProt ID

Q7Z6J6

Alternative Names

FERM Domain Containing 5;

Function

May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675).

May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

Biological Process

Actomyosin structure organization Source: GO_Central
Negative regulation of cell motility Source: UniProtKB
Positive regulation of cell adhesion Source: UniProtKB
Regulation of cell migration Source: UniProtKB

Cellular Location

Membrane; Adherens junction

Topology

Helical: 504-524

References

Lu, S., Ma, M., Mao, X., Bacino, C. A., Jankovic, J., Sutton, V. R., ... & Bellen, H. J. (2022). De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement. The American Journal of Human Genetics, 109(10), 1932-1943.

Gaweł, A. M., Ratajczak, M., Gajda, E., Grzanka, M., Paziewska, A., Cieślicka, M., ... & Godlewska, M. (2021). Analysis of the Role of FRMD5 in the Biology of Papillary Thyroid Carcinoma. International Journal of Molecular Sciences, 22(13), 6726.

Mao, X., Tey, S. K., Ko, F. C. F., Kwong, E. M. L., Gao, Y., Ng, I. O. L., ... & Yam, J. W. P. (2019). C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis. Cancer letters, 444, 60-69.

Gao, H., Yin, R. X., Zhang, Q. H., Qiu, L., Khounphinith, E., Wang, D. S., & Li, K. G. (2018). Association of the FRMD5 rs2929282 polymorphism and serum lipid profiles in two Chinese ethnic groups. International Journal of Clinical and Experimental Pathology, 11(7), 3494.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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