FRMD5

FRMD5 (FERM Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is FRMD3.

Full Name

FERM Domain Containing 5

Function

May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675).

May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

Biological Process

Actomyosin structure organization Source: GO_Central
Negative regulation of cell motility Source: UniProtKB
Positive regulation of cell adhesion Source: UniProtKB
Regulation of cell migration Source: UniProtKB

Cellular Location

Membrane; Adherens junction

Topology

Helical: 504-524

Anti-FRMD5 antibodies

Mouse Anti-FRMD5 Recombinant Antibody (CBXF-1798) (CBMAB-F3333-CQ)

Datasheet

SDS

Target: FRMD5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1798

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)