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Mouse Anti-FSHB Recombinant Antibody (SPM107) (CBMAB-F1295-CQ)

This product is a mouse antibody that recognizes FSHB. The antibody SPM107 can be used for immunoassay techniques such as: IHC-P, IF, FC.
See all FSHB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SPM107
Antibody Isotype
IgG1, κ
Application
IHC-P, IF, FC

Basic Information

Immunogen
Full length purified hFSH
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1 mg/ml BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Follicle Stimulating Hormone Beta Subunit
Introduction
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
Entrez Gene ID
2488
UniProt ID
P01225
Alternative Names
Follicle Stimulating Hormone Beta Subunit; Follicle Stimulating Hormone, Beta Polypeptide; Follitropin, Beta Chain; FSH-Beta; FSH-B; Follicle-Stimulating Hormone Beta Subunit; Follitropin Subunit Beta; Follitropin Beta Chain; HH24;
Function
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546).

Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).
Biological Process
Female gamete generation Source: ProtInc
Female pregnancy Source: ProtInc
Follicle-stimulating hormone signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Hormone-mediated signaling pathway Source: GO_Central
Positive regulation of bone resorption Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of steroid biosynthetic process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Progesterone biosynthetic process Source: BHF-UCL
Regulation of osteoclast differentiation Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Sertoli cell proliferation Source: Ensembl
Spermatogenesis Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Cellular Location
Secreted. Efficient secretion requires dimerization with CGA.
Involvement in disease
Hypogonadotropic hypogonadism 24 without anosmia (HH24):
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility.

Byambaragchaa, M., Park, A., Gil, S. J., Lee, H. W., Ko, Y. J., Choi, S. H., ... & Min, K. S. (2021). Luteinizing hormone-like and follicle-stimulating hormone-like activities of equine chorionic gonadotropin β-subunit mutants in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and rat follicle-stimulating hormone receptor. Animal Cells and Systems, 25(3), 171-181.

Wang, H. Q., Zhang, W. D., Yuan, B., & Zhang, J. B. (2021). Advances in the regulation of mammalian follicle-stimulating hormone secretion. Animals, 11(4), 1134.

Ongaro, L., Schang, G., Zhou, Z., Kumar, T. R., Treier, M., Deng, C. X., ... & Bernard, D. J. (2020). Human follicle-stimulating hormone ß subunit expression depends on FOXL2 and SMAD4. Endocrinology, 161(5), bqaa045.

Santi, D., Crépieux, P., Reiter, E., Spaggiari, G., Brigante, G., Casarini, L., ... & Simoni, M. (2020). Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles. Journal of Clinical Medicine, 9(4), 1014.

Burow, S., Fontaine, R., von Krogh, K., Mayer, I., Nourizadeh-Lillabadi, R., Hollander-Cohen, L., ... & Weltzien, F. A. (2019). Medaka follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh): Developmental profiles of pituitary protein and gene expression levels. General and comparative endocrinology, 272, 93-108.

Trevisan, C. M., de Oliveira, R., Christofolini, D. M., Barbosa, C. P., & Bianco, B. (2019). Effects of a polymorphism in the promoter region of the follicle-stimulating hormone subunit beta (FSHB) gene on female reproductive outcomes. Genetic Testing and Molecular Biomarkers, 23(1), 39-44.

Bousfield, G. R., & Harvey, D. J. (2019). Follicle-stimulating hormone glycobiology. Endocrinology, 160(6), 1515-1535.

Das, N., & Kumar, T. R. (2018). Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. Journal of molecular endocrinology, 60(3), R131.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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