Rabbit Anti-FSTL3 Recombinant Antibody (CBXF-1545) (CBMAB-F1297-CQ)

Name: Rabbit Anti-FSTL3 Recombinant Antibody (CBXF-1545)
SKU: CBMAB-F1297-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-1545

Application

ELISA

Immunogen

Recombinant Mouse FLRG protein

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

follistatin-like 3 (secreted glycoprotein)

Introduction

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.

Entrez Gene ID

83554

UniProt ID

Q9EQC7

Alternative Names

Follistatin Like 3; Follistatin-Like 3 (Secreted Glycoprotein); Follistatin-Related Gene Protein; Follistatin-Like Protein 3; FLRG; Follistatin-Related Protein 3; Follistatin-Related Protein; FSRP;

Function

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Biological Process

Adrenal gland development Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl

Cellular Location

Isoform 1: Secreted
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.

Involvement in disease

A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.

Li, X., Zhang, H., Ma, X., Wang, Y., Han, X., Yang, Y., ... & Bao, Y. (2023). FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation. Obesity, 31(1), 171-183.

Li, C. H., Fang, C. Y., Chan, M. H., Chen, C. L., Chang, Y. C., & Hsiao, M. (2023). The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis. Journal of Cellular and Molecular Medicine.

Liu, Y. J., Li, J. P., Zhang, Y., Nie, M. J., Zhang, Y. H., Liu, S. L., & Zou, X. (2021). FSTL3 is a prognostic biomarker in gastric cancer and is correlated with M2 macrophage infiltration. OncoTargets and therapy, 14, 4099.

Sun, F., Sun, P., Yang, X., Hu, L., Gao, J., & Tian, T. (2021). Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway. Aging (Albany NY), 13(18), 22528.

Brown, M. L., Lopez, A., Meyer, N., Richter, A., & Thompson, T. B. (2021). FSTL3-Neutralizing antibodies enhance glucose-responsive insulin secretion in dysfunctional male mouse and human islets. Endocrinology, 162(10).

He, J., Liu, Q., Yu, S., Lei, M., Liu, J., Di, R., ... & Chu, M. (2021). Expression and functional analysis of the Follistatin‐like 3 (FSTL3) gene in the sheep ovary during the oestrous cycle. Reproduction in Domestic Animals, 56(3), 427-436.

Li, J., Shen, J., Qin, L., Lu, D., & Ding, E. (2021). LBX2-AS1 activates FSTL3 by binding to transcription factor RARα to foster proliferation, migration, and invasion of thyroid cancer. Frontiers in Genetics, 2255.

Gao, L., Chen, X., Wang, Y., & Zhang, J. (2020). Up-regulation of FSTL3, regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, promotes proliferation and migration of non-small cell lung Cancer cells. OncoTargets and therapy, 13, 2725.

Runhua, M., Qiang, J., Yunqing, S., Wenjun, D., & Chunsheng, W. (2019). FSTL3 induces lipid accumulation and inflammatory response in macrophages and associates with atherosclerosis. Journal of Cardiovascular Pharmacology, 74(6), 566-573.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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