FSTL3
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq]
Full Name
follistatin-like 3 (secreted glycoprotein)
Function
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Biological Process
Adrenal gland development Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Isoform 1: Secreted
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
Involvement in disease
A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
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Anti-FSTL3 antibodies
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CompareTarget: FSTL3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G7
Application*: E, E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D6
Application*: E, E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E, E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3214
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2682
Application*: WB, EC
Target: FSTL3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2681
Application*: WB
Target: FSTL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1545
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G7
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D6
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3214
Application*: E
Target: FSTL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2682
Application*: E
Target: FSTL3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2681
Application*: WB
Target: FSTL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1545
Application*: E
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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