FSTL3

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq]

Full Name

follistatin-like 3 (secreted glycoprotein)

Function

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Biological Process

Adrenal gland development Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl

Cellular Location

Isoform 1: Secreted
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.

Involvement in disease

A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.