FSTL3

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq]
Full Name
follistatin-like 3 (secreted glycoprotein)
Function
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Biological Process
Adrenal gland development Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Isoform 1: Secreted
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
Involvement in disease
A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
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Anti-FSTL3 antibodies

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Mouse Anti-FSTL3 Recombinant Antibody (2G7) (CBMAB-A3190-LY)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G7
Application*: E, E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (1D6) (CBMAB-A3188-LY)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D6
Application*: E, E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (2E7) (CBMAB-A3186-LY)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E, E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (CBXF-3214) (CBMAB-F3909-CQ)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3214
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (CBXF-2682) (CBMAB-F3089-CQ)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2682
Application*: WB, EC
Datasheet SDS

Rat Anti-FSTL3 Recombinant Antibody (CBXF-2681) (CBMAB-F3088-CQ)

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Target: FSTL3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2681
Application*: WB
Datasheet SDS

Rabbit Anti-FSTL3 Recombinant Antibody (CBXF-1545) (CBMAB-F1297-CQ)

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Target: FSTL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1545
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (2G7) (V2LY-1225-LY184)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G7
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (1D6) (V2LY-1225-LY183)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D6
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (2E7) (V2LY-1225-LY182)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (CBXF-3214) (V2LY-1225-LY181)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3214
Application*: E
Datasheet SDS

Mouse Anti-FSTL3 Recombinant Antibody (CBXF-2682) (V2LY-1225-LY180)

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Target: FSTL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2682
Application*: E
Datasheet SDS

Rat Anti-FSTL3 Recombinant Antibody (CBXF-2681) (V2LY-1225-LY179)

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Target: FSTL3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2681
Application*: WB
Datasheet SDS

Rabbit Anti-FSTL3 Recombinant Antibody (CBXF-1545) (V2LY-1225-LY178)

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Target: FSTL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1545
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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